Category Archives: General HIV+ population
Reviews on HIV+ people where the population is not specified
Artificial intelligence for predicting antiretroviral therapy outcomes in people living with HIV: A systematic review of predictive models, predictors and clinical readiness
BACKGROUND: Machine learning (ML), deep learning (DL) and other predictive modelling approaches are increasingly applied to predict antiretroviral therapy (ART) outcomes among people living with HIV, yet their methodological robustness...
Integrated service delivery models for triple elimination of mother to child transmission of human immunodeficiency virus, syphilis, and hepatitis B virus: A global systematic review and meta-analysis
BACKGROUND AND OBJECTIVES: Despite global commitment to the World Health Organization triple elimination initiative, evidence on integrated antenatal service delivery models that simultaneously address human immunodeficiency virus (HIV), syphilis, and...
The gut-immune axis in treated HIV infection: From mucosal damage to chronic inflammation and therapeutic opportunities—A clinician-oriented narrative review
Combined antiretroviral therapy (cART) has transformed HIV into a manageable chronic disease. However, people living with HIV (PLWH) experience a 16-year reduction in comorbidity-free life expectancy compared to HIV-negative individuals,...
Perspective of people living with HIV and healthcare workers on the uptake, barriers, and benefits of multimonth dispensing: A qualitative systematic review
INTRODUCTION: Multimonth dispensing (MMD) is a strategy in the HIV care continuum for people living with HIV (PLWH), especially for those who are virally suppressed. With the increase in MMD...
Simulation modeling for the design and evaluation of HIV drug resistance interventions: A systematic review of literature
Background The utility of antiretroviral therapy (ART) in the management of human immunodeficiency virus (HIV) is being challenged by growing HIV drug resistance (HIVDR). Although simulation modelling is useful for...
Integration of HIV, Hepatitis B, and C, and sexually transmitted infections services: A scoping review of the benefits and challenges
BACKGROUND: Integrating clinical programs and services is a cost-effective approach that can improve health and system outcomes. This review aimed to provide an overview of the benefits and challenges of...
Interventions to improve access to sexual and reproductive health services for adolescents living with HIV in sub-Saharan Africa: A scoping review
OBJECTIVE: Adolescents living with HIV (ALHIV) face barriers to accessing sexual and reproductive health (SRH) services, negatively affecting their health and quality of life. These challenges are particularly pronounced in...
Prevalence and risk factors for cytomegalovirus retinitis among people living with HIV in sub-Saharan Africa in the antiretroviral therapy era: A systematic review and meta-analysis
Cytomegalovirus retinitis has remained an alarming and potentially vision-threatening opportunistic disease in the population living with HIV, especially in cases of extreme immunosuppression. Although the introduction of antiretroviral therapy has...
Integrating smoking cessation into HIV care settings: A systematic review and meta-analysis of effectiveness and the evidence gap in cost-effectiveness
The prevalence of smoking among people living with HIV (PLWH) is higher than in the general population, and PLWH who smoke are at increased risk of both smoking- and HIV-related...
Exercise as a preventive and therapeutic strategy for non-communicable diseases in people living with HIV: Evidence, mechanisms and clinical implications
Objective To synthesise evidence on exercise for preventing and managing non-communicable diseases (NCDs) among HIV clients, emphasising sub-Saharan Africa. Design Narrative review. Data sources Meta-analyses, randomised trials, cohort studies, mechanistic...
Prevalence, genetic diversity, and risk factors of cryptosporidium spp. in HIV/AIDS patients: An updated systematic review and meta-analysis (2017–2025)
Background Cryptosporidium spp. is a major opportunistic pathogens in HIV/AIDS patients, contributing substantially to morbidity and mortality worldwide. Despite advances in HIV/AIDS management, the global burden, genetic diversity, and risk factors...
Integrated care models for HIV, diabetes and hypertension in sub-Saharan Africa: A systematic review of effectiveness, implementation and real-world applicability
Background Sub-Saharan Africa faces a syndemic of HIV and non-communicable diseases (NCDs), particularly diabetes and hypertension. Integrated care models have been promoted to improve service efficiency and patient outcomes; however,...
