Category Archives: General HIV+ population
Reviews on HIV+ people where the population is not specified
Effect of human immunodeficiency virus on lung function and structure: A systematic review and meta-analysis
Rationale: Obstructive lung disease (OLD) pathogenesis includes inhalational (e.g., smoking) and noninhalational mechanisms (e.g., infections). Human immunodeficiency virus (HIV) has been suggested as a novel OLD risk factor. Substantial data...
Wealth, income and HIV in sub-Saharan Africa: A systematic review
INTRODUCTION: While economic vulnerability is an established driver of health disparities, the relationships between HIV and wealth, income, and economic inequality have been less consistently established. We conducted a systematic...
Effect of same-day HIV treatment initiation (SDI) on 1-year outcomes in low- and middle-income countries: Systematic review and meta-analysis of randomised trials
Introduction Same-day initiation (SDI) of antiretroviral therapy is recommended for people presenting with HIV who have no contraindications. We reviewed the evidence on SDI interventions in low- and middle-income countries...
Efficacy of raltegravir in achieving virological suppression at delivery in HIV-positive pregnant women: A systematic review and meta-analysis
Background The world’s first HIV integrase inhibitor, raltegravir (RAL), has been widely used for the treatment of HIV infection over the past 15 years, and continues benefiting people living with...
The prevalence of adverse drug reactions to antiretroviral therapy and associated factors among pediatric patients living with HIV in sub-Saharan African countries: A systematic review and meta-analysis
Introduction The greatest burden of HIV infection is in sub-Saharan African countries. The burden of treatment failure among children living with HIV remains significantly high due to delayed diagnosis and...
Risk of hepatitis C virus reinfection after direct-acting antiviral treatment among HIV-positive men who have sex with men and people who inject drugs: A systematic review and meta-analysis
The incidence of hepatitis C virus (HCV) reinfection following successful direct-acting antiviral therapy in HIV/HCV co-infected individuals remains a significant public health concern. This study aimed to estimate the reinfection...
Microalbuminuria among HIV/AIDS patients in Africa: A systematic review and meta-analysis
Background Over the past decade, the incidence of chronic kidney disease among HIV-seropositive people has increased at an alarming rate. Microalbuminuria is believed to be a precursor of HIV-related renal...
Long-acting injectable cabotegravir and rilpivirine in observational cohort studies: A systematic review on virological failure, resistance and re-suppression outcomes in virally suppressed individuals living with HIV
Introduction Randomized controlled trial evidence suggests that long‐acting injectable (LA‐I) cabotegravir and rilpivirine (CAB+RPV) has similar virological failure (VF) rates to daily oral therapy, but clinical practice evidence is lacking....
Dolutegravir + lamivudine effectiveness and tolerability in real-world cohorts with HIV-1 across Asia and South America: A systematic literature review
Background: Dolutegravir (DTG) + lamivudine (3TC) has demonstrated efficacy and safety in phase 3 clinical trials; however, most published data are from people with HIV-1 in North America and Europe. Methods: To...
Gut microbiota of sub-Saharan Africa infants exposed to antiretroviral therapy: Scoping review
Background Antiretroviral (ARV) exposure influences the early-life gut microbiota in regions with high human immunodeficiency virus (HIV) burdens. Understanding how ARV drugs affect the infant gut microbiota is important for...
Evaluating the impact of COVID-19 on the HIV care continuum across global income levels: A mixed-methods systematic review
BACKGROUND: The COVID-19 pandemic caused significant disruptions to global healthcare systems, including essential services along the HIV care continuum (HCC). While several studies have examined these impacts in specific countries...
