Category Archives: Older adults (>50 years)

Choosing between dual and three-drug antiretroviral therapy in aging and comorbid people with HIV: A narrative review

2026

The widespread use of combination antiretroviral therapy has transformed HIV infection into a chronic condition, with life expectancy of people with HIV (PWH) approaching that of the general population when...

The benefit of physical exercise in improving quality of life, VO(2) max and sleep quality among older adults living with HIV: A systematic review and meta-analysis

2026

Background: Older adults living with HIV face multiple health challenges, yet evidence on the impact of exercise on their well-being remains limited. Regular physical activity is known to have multiple benefits...

Exploring the potential of cognitive intra-individual variability in HIV care and research in adults with HIV: A concept analysis

2026

Cognitive intraindividual variability (IIV) refers to the variability in one’s ability to sustain consistent cognitive performance. This phenomenon is linked to the emergence of cognitive impairment and dementia. The aim...

Prevalence of hypertension, diabetes, obesity, and high cholesterol among older people living with HIV: A systematic review and meta-analysis

2026

INTRODUCTION: Metabolic comorbidities are significant health challenges for older people living with HIV (PLHIV). This systematic review and meta-analysis aimed to synthesize existing evidence and provide the pooled prevalence of...

Facilitators and barriers to physical activity in middle-aged and older adult(s) HIV infected persons: A systematic review of qualitative studies

2026

PURPOSE: This study aims to objectively evaluate and synthesize qualitative studies on the facilitators and barriers to PA among middle-aged and older adults living with HIV. METHODS: A systematic search...

Colorectal cancer screening uptake and lesion detection in people living with HIV: A systematic review and meta-analysis

2026

Introduction: As people living with HIV age, the absolute colorectal cancer (CRC) burden rises, yet the extent of routine CRC screening delivery and clinical yield is unclear. We synthesized evidence on...

Global prevalence and biopsychosocial correlates of psychological distress among people living with HIV: An updated theory-informed meta-analysis

2026

Introduction:  Psychological distress (PD) is common among people living with HIV (PLWH), but prevalence estimates vary substantially. This study aimed to synthesize the prevalence of PD among PLWH and examine...

The impact of APOE ε4 on cognitive performance in adults with HIV: A systematic review and meta-analysis

2026

Objective: With a rapidly aging population living with HIV that may face a double-hit of neuroHIV and Alzheimer’s disease, the objective of this meta-analysis was to evaluate the impact of...

The burden of sarcopenia in people living with HIV: A systematic review and meta-analysis across WHO regions

2026

BACKGROUND: Sarcopenia, characterized by progressive loss of skeletal muscle mass and function, represents an underrecognized comorbidity in people living with human immunodeficiency virus, and comprehensive prevalence data across WHO regions...

The prevalence and influencing factors of frailty among middle-aged and older adults with HIV/AIDS from a global perspective: A systematic review and meta-analysis

2026

Aim: Currently, frailty has become a central issue in health management among middle-aged and older people living with HIV/AIDS (PLWHA) worldwide. The objective is to develop targeted strategies to improve frailty...

Polypharmacy in HIV: Rethinking what counts and why it matters

2025

Polypharmacy, the concurrent use of multiple medications, presents a growing challenge in HIV care as people living with HIV age and experience earlier onset of age-related co-morbidities. However, how polypharmacy...

Risk factors for HIV-associated neurocognitive impairment and frailty in aging people with HIV in Latin America: A systematic review

2026

Background As people living with HIV (PWH) in Latin America and the Caribbean (LAC) have longer life expectancy due to improved access to antiretroviral therapy (ART), complications such as HIV-associated...

Email 1 selected articles

Email 1 selected articles

Error! The email wasn't sent. Please try again.

Your email has been sent!