Category Archives: Prevention, Engagement and Care Cascade
Long-acting injectable cabotegravir and rilpivirine in observational cohort studies: A systematic review on virological failure, resistance and re-suppression outcomes in virally suppressed individuals living with HIV
Introduction Randomized controlled trial evidence suggests that long‐acting injectable (LA‐I) cabotegravir and rilpivirine (CAB+RPV) has similar virological failure (VF) rates to daily oral therapy, but clinical practice evidence is lacking....
Barriers to and facilitators of heterosexual men’s engagement with the PrEP care continuum in Sub-Saharan Africa: A scoping review
The HIV epidemic in sub-Saharan Africa (SSA) continues to spread primarily through heterosexual contact, and in many countries, heterosexual men continue to exhibit a high HIV incidence with resultant morbidity...
Dolutegravir + lamivudine effectiveness and tolerability in real-world cohorts with HIV-1 across Asia and South America: A systematic literature review
Background: Dolutegravir (DTG) + lamivudine (3TC) has demonstrated efficacy and safety in phase 3 clinical trials; however, most published data are from people with HIV-1 in North America and Europe. Methods: To...
Gut microbiota of sub-Saharan Africa infants exposed to antiretroviral therapy: Scoping review
Background Antiretroviral (ARV) exposure influences the early-life gut microbiota in regions with high human immunodeficiency virus (HIV) burdens. Understanding how ARV drugs affect the infant gut microbiota is important for...
Evaluating the impact of COVID-19 on the HIV care continuum across global income levels: A mixed-methods systematic review
BACKGROUND: The COVID-19 pandemic caused significant disruptions to global healthcare systems, including essential services along the HIV care continuum (HCC). While several studies have examined these impacts in specific countries...
Psychosocial experience and coping of AIDS patients about the disease: A systematic review and qualitative meta-synthesis
AIM: To systematically integrate the psychosocial experiences and coping mechanisms of AIDS patients after the disease, and to understand their true feelings, in order to provide a basis for better...
Reducing HIV risk behaviors among Black women living with and without HIV/AIDS in the U.S.: A systematic review
This systematic review provides an examination of the status of HIV/AIDS prevention interventions for Black, heterosexual women in the U.S. from 2012 to 2019. Using PRISMA guidelines, 28 interventions were...
Studied factors and metrics of patient portal use among people with HIV: A rapid scoping review
For people living with HIV (PLHIV), patient portals could facilitate access to personal health records while promoting self-management and retention in care. Given the apparent heterogeneity in the studied factors...
Incidence and predictors of attrition among children on antiretroviral therapy in Ethiopia: A systematic review and meta-analysis
Objective To estimate the pooled attrition rate among HIV-infected children receiving antiretroviral therapy (ART) and identify predictors of attrition in Ethiopia. Design Systematic review and meta-analysis. Data sources PubMed, HINARI,...
Oral pre-exposure prophylaxis initiation, continuation and adherence among pregnant and postpartum women receiving antenatal and postnatal care: A systematic review
INTRODUCTION: In 2023, one-fourth of new HIV acquisitions in children globally resulted from vertical transmission following incident HIV during pregnancy or breastfeeding. Oral pre-exposure prophylaxis (PrEP) with tenofovir disoproxil and...
Safety, tolerability, and metabolic effects of long-acting cabotegravir and rilpivirine in HIV care: A comprehensive review
The use of long-acting cabotegravir and rilpivirine (LA CAB/RPV) is a novel approach to manage human immunodeficiency virus (HIV). This injectable regimen offers benefits such as an improved quality of...
Barriers and facilitators to engagement with the PrEP care continuum among sexual minority men in China: A systematic review
Sexual minority men (SMM) in China are disproportionately affected by the HIV epidemic, yet utilization of HIV prevention services, such as pre-exposure prophylaxis (PrEP), remains low. This systematic review summarizes...
