Category Archives: Prevention, Engagement and Care Cascade
Perinatal outcomes associated with pre-exposure prophylaxis for HIV prevention during pregnancy: A systematic review and meta-analysis
Background The World Health Organization (WHO) recommends tenofovir disoproxil fumarate (TDF)-based oral pre-exposure prophylaxis (PrEP), the dapivirine vaginal ring, and long-acting intramuscular injectable cabotegravir (CAB-LA) for HIV prevention in populations...
Immunogenicity and safety of live attenuated and recombinant/inactivated varicella zoster vaccines in people living with HIV: A systematic review
Few papers focus their attention on VZV vaccination effectiveness among people living with HIV (PLWH). Flanking the live attenuated vaccine (VZL) available, a newly recombinant vaccine (RZV) was recently introduced...
Second-line anti-retroviral treatment failure and its predictors among patients with HIV in Ethiopia: A systematic review and meta-analysis
Antiretroviral therapy (ART) treatment failure remains a major public health concern, with multidimensional consequences, including an increased risk of drug resistance, compromised quality of life, and high healthcare costs. However,...
Virological suppression and its predictors among HIV/AIDS patients on antiretroviral therapy in Ethiopia: Systematic review and meta-analysis
BACKGROUND: Achieving viral load suppression is crucial for the prevention of complications and deaths related to HIV infection. Ethiopia has embraced the worldwide 95-95-95 target, but there is no national...
Immunocompromised individuals are at increased risk of COVID-19 breakthrough infection, hospitalization, and death in the post-vaccination era: A systematic review
Introduction Immunocompromised individuals have been shown to mount a reduced response to vaccination, resulting in reduced vaccine effectiveness in this cohort. Therefore, in the postvaccination era, immunocompromised individuals remain at...
Family planning counseling for women living with HIV in low- and middle-income countries: A systematic review of the impact on contraceptive uptake, intention to use contraception and pregnancy incidence, 2011 to 2022
Women’s ability to control their fertility and have the number of children they want when they want them is an internationally recognized human right. This right has been the driving...
Level of adherence to option B+ program and associated factors among HIV-positive women in Ethiopia: A systematic review and meta-analysis
BACKGROUND: Despite policy initiatives and strategic measures highly focused on preventing mother-to-child transmission through the implementation of the Option B+ program, adherence to the treatment is still challenging. The level...
Systematic review of the impact of protease inhibitor-based combination antiretroviral therapy on renal transplant outcomes in recipients living with HIV infection
Advances in Human Immunodeficiency Virus (HIV) treatment including combination antiretroviral therapy (cART) have transformed HIV into a chronic condition. Kidney diseases cause morbidity and mortality in patients living with HIV...
Higher cardiovascular disease risks in people living with HIV: A systematic review and meta-analysis
Background The prognosis of AIDS after active antiretroviral therapy (ART) and the quality of life of people living with HIV (PLWH) are both affected by non-AIDS-related diseases such as cardiovascular...
The impact of HIV pre-exposure prophylaxis on bacterial sexually transmitted infection occurrence in MSM: A systematic review and meta-analysis
Objective: To evaluate the effect of preexposure prophylaxis (PrEP) initiation on bacterial sexually transmitted infection (STI) occurrence (overall; chlamydia; gonorrhea; syphilis), in MSM. Design: Systematic review and meta-analysis. Methods: Systematic searches were...
Improving delivery and use of HIV pre-exposure prophylaxis in the US: A systematic review of implementation strategies and adjunctive interventions
Implementation of pre-exposure prophylaxis (PrEP) to prevent HIV transmission is suboptimal in the United States. To date, the literature has focused on identifying determinants of PrEP use, with a lesser...
