Category Archives: Treatment
Prevalence and risk factors for oropharyngeal, esophageal, and oral candidiasis in HIV-positive individuals: A systematic review and meta-analysis
Background: Oral, oropharyngeal, and esophageal candidiasis are common forms of mucosal candidiasis (MC) in people living with human immunodeficiency virus/acquired immunodeficiency syndrome (PLWHA). Despite differences in infection sites, oral, oropharyngeal, and...
Interventions to increase adherence to antiretroviral therapy in people living with HIV—what works? A systematic review and meta-analysis
The Perceptions and Practicalities Approach (PaPA) is a recommended framework for designing medication adherence interventions. Little is known about the utility of the PaPA framework in improving antiretroviral therapy (ART)...
The mental health of adults living with HIV in sub-Saharan Africa: Interventions along the HIV care continuum—A systematic review
Although the relationship between HIV and mental health is well-established, limited research has focused on the available interventions for adults living with HIV (ALWH), particularly those in sub-Saharan Africa (SSA)...
Can ChatGPT match physicians in the diagnosis, triage, management and prevention of infectious diseases? A scoping review
INTRODUCTION: The global burden of infectious diseases (ID), combined with a shortage of ID specialists, continues to challenge healthcare systems worldwide. Artificial intelligence (AI), particularly large language models such as...
Choosing between dual and three-drug antiretroviral therapy in aging and comorbid people with HIV: A narrative review
The widespread use of combination antiretroviral therapy has transformed HIV infection into a chronic condition, with life expectancy of people with HIV (PWH) approaching that of the general population when...
Dysregulated metabolism in people living with HIV in the modern ART-era: A systematic review of targeted metabolomics studies
HIV remains a significant public health issue, with 1.3 million new infections and 630,000 deaths annually, and 40.8 million people living with HIV (PLHIV) globally in 2024. Although antiretroviral therapy...
Maternal-to-child-transmission of human immunodeficiency virus in maternal preterm premature rupture of the membranes: A systematic review
Aim: Preterm premature rupture of membranes (PPROM) in the context of maternal human immunodeficiency virus (HIV) infection poses a significant clinical dilemma, as clinicians must balance the risks of prematurity with...
Perinatal outcomes associated with antiretroviral therapy for pregnant women living with HIV: An umbrella review
Background: The World Health Organization recommends antiretroviral therapy (ART) for pregnant women living with HIV (WLHIV), the vast majority of whom reside in sub-Saharan Africa. In recent years, many systematic reviews,...
Implementation of therapeutic adherence in adult patients diagnosed with the human immunodeficiency virus: A systematic review
OBJECTIVES: To systematically map and summarize the available knowledge on interventions that promote medication adherence among adult HIV patients and to describe the current state of the art regarding the...
Effectiveness of digital health interventions on antiretroviral therapy adherence among people living with HIV in India: A systematic review with an RCT-only meta-analysis
The widespread use of combination antiretroviral therapy has transformed HIV infection into a chronic condition, with life expectancy of people with HIV (PWH) approaching that of the general population when...
Impact of dolutegravir-based regimens on patient satisfaction and quality of life among people living with HIV: A systematic review and meta-analysis
Background Despite the global scale up of dolutegravir (DTG)-based regimens as the preferred first-line therapy for persons living with HIV (PLHIV), no comprehensive evidence exists on its effect on patient-reported...
The burden of HIV-related stigma on clinical and quality of life outcomes: results from a systematic literature review
BACKGROUND: HIV-related stigma adversely impacts people with HIV. As part of a systematic literature review (SLR) to evaluate 6 research questions on HIV-related stigma among people with HIV, data from...
