Category Archives: Treatment

Non-nucleoside reverse transcriptase inhibitor- versus ritonavir-boosted protease inhibitor-based regimens for initial treatment of HIV infection: A systematic review and meta-analysis of randomised trials

2016

BACKGROUND: Previous studies suggest that nonnucleoside reverse-transcriptase inhibitors (NNRTIs) cause faster virologic suppression, while ritonavir-boosted protease inhibitors (PI/r) recover more CD4 cells. However, individual trials have not been powered to...

Incidence of opportunistic infections and the impact of antiretroviral therapy among HIV-infected adults in low- and middle-income countries: A systematic review and meta-analysis

2016

BACKGROUND: To understand regional burdens and inform delivery of health services, we conducted a systematic review and meta-analysis to evaluate the effect of antiretroviral therapy (ART) on incidence of key...

Is protease inhibitors based antiretroviral therapy during pregnancy associated with an increased risk of preterm birth? Systematic review and a meta-analysis

2016

BACKGROUND: Antiretroviral therapy is recommended during pregnancy to decrease the risk of perinatal transmission of HIV-1 infection and to improve maternal health. However, some studies have reported that antiretroviral treatment...

Generic antiretroviral drugs and HIV care: An economic review

2016

The cost of HIV care in European countries is high. Direct medical costs, in France, have been estimated at 500,000Euros per patient’s lifetime (20,000 Euros/year/patient). Overall, 73% of these costs...

Antiretroviral therapy among pregnant and postpartum women in China: A systematic review and meta-analysis

2016

BACKGROUND: The objectives of this study were to estimate the antiretroviral therapy (ART) rate and the proportion of women with adequate ART adherence (100%), and to identify the reasons for...

Prevalence and distribution of non-AIDS causes of death among HIV-infected individuals receiving antiretroviral therapy: A systematic review and meta-analysis

2016

The advent of antiretroviral therapy has significantly improved AIDS-related morbidity and mortality. Yet, among people living with HIV, deaths due to non-AIDS-defining illnesses have been on the rise. The objective...

Genetic markers of the host in persons living with HTLV-1, HIV and HCV infections

2016

Human T-cell leukemia virus type 1 (HTLV-1), hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) are prevalent worldwide, and share similar means of transmission. These infections may...

Improving engagement in the HIV care cascade: A systematic review of interventions involving people living with HIV/AIDS as peers

2016

Improving patient engagement in HIV care is critical for maximizing the impact of antiretroviral therapy (ART). We conducted a systematic review of studies that used HIV-positive peers to bolster linkage,...

Adverse events associated with abacavir use in HIV-infected children and adolescents: A systematic review and meta-analysis

2015

BACKGROUND: Concerns exist about the toxicity of drugs used in the implementation of large-scale antiretroviral programmes, and documentation of antiretroviral toxicity is essential. We did a systematic review and meta-analysis...

Systematic review to determine the prevalence of transmitted drug resistance mutations to rilpivirine in HIV-infected treatment-naive persons

2016

BACKGROUND: Transmitted drug resistance to antiretrovirals in HIV-1 infected individuals is rising in some regions, and could compromise the effectiveness of first-line treatment. It is important to understand the prevalence...

Dual therapy treatment strategies for the management of patients infected with HIV: A systematic review of current evidence in ARV-naive or ARV-experienced, virologically suppressed patients

2016

OBJECTIVE: We reviewed the current literature regarding antiretroviral (ARV)-sparing therapy strategies to determine whether these novel regimens can be considered appropriate alternatives to standard regimens for the initial treatment of...

Comparisons of adherence to antiretroviral therapy in a high-risk population in China: A systematic review and meta-analysis

2016

BACKGROUND: Reports on antiretroviral therapy (ART) adherence are scare in China; we performed this meta-analysis to estimate ART adherence rates in different populations at high risk for HIV transmission in...

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