Category Archives: Treatment

The association between HIV, antiretroviral therapy and gestational diabetes mellitus: A systematic review and meta-analysis

2017

OBJECTIVES: The widespread, chronic use of antiretroviral therapy (ART) raises questions concerning the metabolic consequences of HIV infection and treatment. Antiretroviral therapy, and specifically protease inhibitors (PIs), has been associated...

Ramadan fasting and infectious diseases: A systematic review

2014

Ramadan represents the fourth of the five pillars of the Islamic creed. Although patients are exempted from observing this duty, they may be eager to share this moment of the...

Suboptimal viral suppression rates among HIV-infected children in low- and middle-income countries: A meta-analysis

2016

BACKGROUND: The 90-90-90 goals aim to achieve viral suppression in 90% of all HIV-infected people on antiretroviral treatment (ART), which is especially challenging in children. Global estimates of viral suppression...

Statistical monitoring-based alarming systems in modeling the AIDS epidemic in the United States, 1985-2011

2015

BACKGROUND: Better decisions for the control of HIV/AIDS and other infectious diseases require better information. The large amount of available public health data makes it possible to extract such information...

The association of HIV-related stigma to HIV medication adherence: A systematic review and synthesis of the literature

2016

This paper provides a review of the quantitative literature on HIV-related stigma and medication adherence, including: (1) synthesis of the empirical evidence linking stigma to adherence, (2) examination of proposed...

A review of HIV-specific patient-reported outcome measures

2016

The use of patient-reported outcome (PRO) measures to provide added feedback to health providers is receiving interest as a means of improving clinical care and patient outcomes, and contributing to...

The impact of alcohol use and related disorders on the HIV continuum of care: A systematic review : Alcohol and the HIV continuum of care

2015

Alcohol use is highly prevalent globally with numerous negative consequences to human health, including HIV progression, in people living with HIV (PLH). The HIV continuum of care, or treatment cascade,...

Antiretroviral therapy adherence enhancing interventions for adolescents and young adults 13–24 years of age: A review of the evidence base

2016

INTRODUCTION: Youth living with HIV are highly under-represented in the evidence base for adherence interventions, despite their diverse and unique needs and barriers. OBJECTIVE: This systematic review aimed to identify...

Dolutegravir(DTG, S/GSK1349572) combined with other ARTs is superior to RAL- or EFV-based regimens for treatment of HIV-1 infection: A meta-analysis of randomized controlled trials

2016

BACKGROUND: The first-generation integrase inhibitors (INIs) raltegravir (RAL) and elvitegravir (EVG) have shown efficacy against HIV infection, but they have the limitations of once-more daily dosing and extensive cross-resistance. Dolutegravir...

Housing stability and medication adherence among HIV-positive individuals in antiretroviral therapy: A meta-analysis of observational studies in the U.S.

2016

BACKGROUND: Previous research has produced inconsistent evidence of an association between housing stability and medication adherence among HIV-positive individuals in antiretroviral therapy. OBJECTIVE: We conducted a meta-analysis of the housing-adherence...

The role of ARV associated adverse drug reactions in influencing adherence among HIV-infected individuals: A systematic review and qualitative meta-synthesis

2016

Poor adherence remains a major barrier to achieving the clinical and public health benefits of antiretroviral drugs (ARVs). A systematic review and qualitative meta-synthesis was conduct to evaluate how ARV...

Comparative efficacy and safety of first-line antiretroviral therapy for the treatment of HIV infection: A systematic review and network meta-analysis

2016

BACKGROUND: New antiretroviral therapy (ART) regimens for HIV could improve clinical outcomes for patients. To inform global guidelines, we aimed to assess the comparative effectiveness of recommended ART regimens for...

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