Category Archives: Treatment
Comparative efficacy of Lamivudine and emtricitabine: A systematic review and meta-analysis of randomized trials
INTRODUCTION: Lamivudine and emtricitabine are considered equivalent by several guidelines, but evidence of comparable efficacy is conflicting. METHODS: We searched two databases up to June 30 2013 to identify randomized...
The effectiveness of probiotics for managing diarrhoea in people with HIV infection: A critically appraised topic
OBJECTIVES: The implications of HIV infection are vast. Management of clinical symptomatology, though, cannot be overshadowed by focus on disease management. These must be managed in concert. Diarrhoea, a common...
Treatment outcomes of treatment-naive Hepatitis C patients co-infected with HIV: A systematic review and meta-analysis of observational cohorts
INTRODUCTION: Co-infection with Hepatitis C (HCV) and HIV is common and HIV accelerates hepatic disease progression due to HCV. However, access to HCV treatment is limited and success rates are...
Complementary and alternative medicine in the management of pain, dyspnea, and nausea and vomiting near the end of life. A systematic review
To review the evidence for efficacy of complementary and alternative medicine (CAM) modalities in treating pain, dyspnea, and nausea and vomiting in patients near the end of life, original articles...
Antiretroviral therapy for prevention of tuberculosis in adults with HIV: A systematic review and meta-analysis
BACKGROUND: Human immunodeficiency virus (HIV) infection is the strongest risk factor for developing tuberculosis and has fuelled its resurgence, especially in sub-Saharan Africa. In 2010, there were an estimated 1.1...
Outcomes for efavirenz versus nevirapine-containing regimens for treatment of HIV-1 infection: A systematic review and meta-analysis
INTRODUCTION: There is conflicting evidence and practice regarding the use of the non-nucleoside reverse transcriptase inhibitors (NNRTI) efavirenz (EFV) and nevirapine (NVP) in first-line antiretroviral therapy (ART). METHODS: We systematically...
Adherence to antiretroviral therapy for pediatric HIV infection: A qualitative systematic review with recommendations for research and clinical management
Although nonadherence to prescribed therapies is widespread, it is particularly problematic with highly active antiretroviral therapy for HIV infection. This review of >50 studies in the area of pediatric HIV...
Effect of hormonal contraceptive methods on HIV disease progression: A systematic review
OBJECTIVE: Systematically assess from the literature whether women living with HIV who use hormonal contraception are at increased risk of HIV-disease progression compared with those who do not use hormonal...
Efficacy of anti-leishmania therapy in visceral leishmaniasis among HIV infected patients: A systematic review with indirect comparison
OBJECTIVE: We conducted a systematic literature review with indirect comparison of studies evaluating therapeutic efficacy and toxicity associated to visceral leishmaniasis (VL) therapy among HIV infected individuals. MAIN OUTCOME MEASUREMENTS:...
Interventions for treating AIDS-associated Hodgkin’ s lymphoma in treatment-naive adults
Background: Hodgkin’s disease (HD) is the most common non-AIDS-defining malignancy in HIV-infected patients. Its unusually aggressive tumour behaviour includes a higher frequency of unfavourable histologic subtypes, high-stage and extranodal involvement...