Category Archives: Treatment
Dual therapy treatment strategies for the management of patients infected with HIV: A systematic review of current evidence in ARV-naive or ARV-experienced, virologically suppressed patients
OBJECTIVE: We reviewed the current literature regarding antiretroviral (ARV)-sparing therapy strategies to determine whether these novel regimens can be considered appropriate alternatives to standard regimens for the initial treatment of...
Comparisons of adherence to antiretroviral therapy in a high-risk population in China: A systematic review and meta-analysis
BACKGROUND: Reports on antiretroviral therapy (ART) adherence are scare in China; we performed this meta-analysis to estimate ART adherence rates in different populations at high risk for HIV transmission in...
Assessing the role of masculinity in the transmission of HIV: A systematic review to inform HIV risk reduction counseling interventions for men who have sex with men
HIV affects over 1.2 million people in the United States; a substantial number are men who have sex with men (MSM). Despite an abundance of literature evaluating numerous social/structural and...
Does food insecurity undermine adherence to antiretroviral therapy? A systematic review
A growing body of research has identified food insecurity as a barrier to antiretroviral therapy (ART) adherence. We systematically reviewed and summarized the quantitative literature on food insecurity or food...
Association of HLA-B*5701 genotypes and abacavir-induced hypersensitivity reaction: A systematic review and meta-analysis
OBJECTIVES: This study aimed to systematically review and quantitatively synthesize the association between HLA-B*5701 and abacavir-induced hypersensitivity reaction (ABC-HSR). METHODS: We searched for studies that investigated the association between HLA-B...
Treatment of acute hepatitis C infection with pegylated interferon and ribavirin in patients coinfected with human immunodeficiency virus: A systematic review and meta-analysis
BACKGROUND/AIMS: Of the 35 million human immunodeficiency virus (HIV)-positive patients worldwide, 10-40% are coinfected with chronic hepatitis C virus (HCV). Compared to HCV-monoinfected patients, those coinfected experience decreased spontaneous HCV...
Optimal timing of antiretroviral therapy initiation for HIV-infected adults with newly diagnosed pulmonary tuberculosis: A systematic review and meta-analysis
BACKGROUND: Initiation of antiretroviral therapy (ART) during tuberculosis (TB) treatment remains challenging. PURPOSE: To assess evidence from randomized, controlled trials of the timing of ART initiation in HIV-infected adults with...
Leishmaniasis as a manifestation of immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients: A literature review
INTRODUCTION: After the onset of highly active antiretroviral therapy (HAART), some HIV-infected patients present a severe inflammation in response to a latent or a previously treated opportunistic pathogen termed immune...
Viral suppression in adolescents on antiretroviral treatment: Review of the literature and critical appraisal of methodological challenges
OBJECTIVE: Medication adherence is often sub-optimal for adolescents with HIV, and establishing correct weight-based antiretroviral therapy dosing is difficult, contributing to virological failure. This review aimed to determine the proportion...
The effect of tuberculosis treatment on virologic and CD4+ cell count response to combination antiretroviral therapy: A systematic review
OBJECTIVES: To determine the impact of tuberculosis (TB) treatment at the time of combination antiretroviral therapy (cART) initiation on virologic and CD4 cell count response to cART. METHODS:: Systematic review...
Adherence to antiretroviral therapy in adolescents living with HIV: Systematic review and meta-analysis
OBJECTIVE: Adolescent and young adult (AYA) populations (12-24 years) represent over 40% of new HIV infections globally. Adolescence is sometimes characterized by high-risk sexual behaviour and a lack of engagement...
