Category Archives: Treatment

Eliminating mother-to-child transmission of the human immunodeficiency virus in sub-Saharan Africa: The journey so far and what remains to be done

2015

This review was carried out to provide a comprehensive overview of efforts toward elimination of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) with respect to progress, challenges, and recommendations...

Heterosexual risk of HIV transmission per sexual act under combined antiretroviral therapy: Systematic review and bayesian modeling

2014

BACKGROUND: Although essential for patient counseling and quality of life of human immunodeficiency virus (HIV)-infected individuals, the risk of HIV transmission during 1 unprotected sex act with an HIV-infected person...

Efficacy of protease inhibitor monotherapy vs. triple therapy: Meta-analysis of data from 2303 patients in 13 randomized trials

2016

OBJECTIVES: The aim of this analysis was to review the evidence and update a meta-analysis evaluating the efficacy and safety results from randomized controlled trials of ritonavir-boosted protease inhibitor (PI/r)...

The impact of specific HIV treatment-related adverse events on adherence to antiretroviral therapy: A systematic review and meta-analysis

2013

Poor adherence to antiretroviral therapies (ARTs) in human immunodeficiency virus (HIV)-infected patients increases the risk of incomplete viral suppression, development of viral resistance, progression to acquired immune deficiency syndrome and...

Early initiation of antiretroviral therapy in HIV-infected adults and adolescents: A systematic review

2014

OBJECTIVES: The objective of this review was to update evidence on when to initiate antiretroviral therapy (ART) to inform revision of the 2013 WHO guidelines for ART in low and...

The prevalence of HIV-1 drug resistance among antiretroviral treatment naïve individuals in mainland China: A meta-analysis

2014

BACKGROUND: Surveillance of drug resistance in antiretroviral treatment-naive patients in China is needed to ensure optimal treatment outcomes and control of the human immunodeficiency virus (HIV) epidemic. METHODS: A systematic...

Metabolic complications of in utero maternal HIV and antiretroviral exposure in HIV-exposed infants

2014

BACKGROUND: Despite a wide body of literature supporting the use of antenatal antiretrovirals (ARV) for the prevention of mother-to-child transmission, there remains a need for continued monitoring as the intrauterine...

Service delivery interventions to improve adolescents’ linkage, retention and adherence to antiretroviral therapy and HIV care

2015

OBJECTIVES: Adolescents living with HIV face substantial difficulties in accessing HIV care services and have worse treatment outcomes than other age groups. The objective of this review was to evaluate...

Comparative effectiveness of tenofovir in treatment-naive HIV-infected patients: Systematic review and meta-analysis

2015

INTRODUCTION: Benefits and harms of tenofovir disoproxil fumarate (TDF) in HIV-infected, antiretroviral treatment (ART)-naive patients of any age have not been systematically reviewed since recent milestone trials were published. METHODS:...

Long-term virological outcomes of first-line antiretroviral therapy for HIV-1 in low- and middle-income countries: A systematic review and meta-analysis

2015

BACKGROUND: More than 11.7 million people are currently receiving antiretroviral therapy (ART) in low- and middle-income countries (LMICs), and focused efforts are needed to ensure high levels of adherence and...

Social media and HIV: A systematic review of uses of social media in HIV communication

2015

BACKGROUND: Social media, including mobile technologies and social networking sites, are being used increasingly as part of human immunodeficiency virus (HIV) prevention and treatment efforts. As an important avenue for...

Interventions to promote adherence to antiretroviral therapy in Africa: A network meta-analysis

2014

BACKGROUND: Adherence to antiretroviral therapy (ART) is necessary for the improvement of the health of patients and for public health. We sought to determine the comparative effectiveness of different interventions...

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