Category Archives: Treatment
A meta-analysis of the performance of the Pima CD4 for point of care testing
BACKGROUND: The Alere point-of-care (POC) Pima CD4 analyzer allows for decentralized testing and expansion to testing antiretroviral therapy (ART) eligibility. A consortium conducted a pooled multi-data technical performance analysis of...
Basis of selection of first and second line highly active antiretroviral therapy for HIV/AIDS on genetic barrier to resistance: A literature review
Long-term management of HIV/AIDS is at risk of increasing drug resistance1. Booster protease inhibitor (PI) and thymidine analogue-containing regimens have a high genetic barrier to resistance. Non-thymidine-analogue triple nucleoside/nucleotide reverse...
Identification of evidence-based interventions for promoting HIV medication adherence: Findings from a systematic review of U.S.-based studies, 1996-2011.
A systematic review was conducted to identify evidence-based interventions (EBIs) for increasing HIV medication adherence behavior or decreasing HIV viral load among persons living with HIV (PLWH). We conducted automated...
Comparisons of disparities and risks of HIV infection in black and other men who have sex with men in Canada, UK, and USA: A meta-analysis
BACKGROUND: We did a meta-analysis to assess factors associated with disparities in HIV infection in black men who have sex with men (MSM) in Canada, the UK, and the USA....
Tipranavir: The first nonpeptidic protease inhibitor for the treatment of protease resistance
Background: Despite the availability of a growing number of potent antiretroviral agents, efforts to completely suppress viral replication in patients with HIV-1 infection are limited because of the increasing risk...
Limited benefit of antiretroviral resistance testing in treatment-experienced patients: A meta-analysis
OBJECTIVE: To estimate the effectiveness of resistance assessments based on viral sequencing (genotypic antiretroviral resistance testing, GART), phenotypic antiretroviral resistance testing (PART) or virtual PART (vPART) in the management of...
Antiretroviral therapy uptake, attrition, adherence and outcomes among HIV-infected female sex workers: A systematic review and meta-analysis.
PURPOSE: We aimed to characterize the antiretroviral therapy (ART) cascade among female sex workers (FSWs) globally. METHODS: We systematically searched PubMed, Embase and MEDLINE in March 2014 to identify studies...
Treatment outcomes after highly active antiretroviral therapy: A meta-analysis of randomised controlled trials
This systematic review summarises the evidence for treatment efficacy and tolerability of highly active antiretroviral therapies containing two nucleoside reverse transcriptase inhibitors (NRTI) with a protease inhibitor (PI), compared with...
Integrating prevention of mother-to-child HIV transmission programs to improve uptake: A systematic review
Background: We performed a systematic review to assess the effect of integrated perinatal prevention of mother-to-child transmission of HIV interventions compared to non- or partially integrated services on the uptake...
Modeling the cost-effectiveness of HIV treatment: how to buy the most ‘health’ when resources are limited
PURPOSE OF REVIEW: To summarize recent cost-effectiveness analyses (CEAs) that evaluate optimal treatment strategies for persons living with HIV/AIDS (PLWHA). RECENT FINDINGS: Efforts to attain universal coverage of current treatment...
