Category Archives: Treatment
Global burden of transmitted HIV drug resistance and HIV-exposure categories: A systematic review and meta-analysis
OBJECTIVES: Our aim was to review the global disparities of transmitted HIV drug resistance (TDR) in antiretroviral-naive MSM, people who inject drugs (PWID) and heterosexual populations in both high-income and...
Systematic literature review and meta-analysis of renal function in human immunodeficiency virus (HIV)-infected patients treated with Atazanavir (ATV)-based regimens
Some HIV antiretroviral therapies (ART) have been associated with renal toxicities, which become of increasing concern as HIV-infected patients age and develop comorbidities. The objective of this study was to...
Review: An urgent need for research on factors impacting adherence to and retention in care among HIV-positive youth and adolescents from key populations
INTRODUCTION: The 50% increase in HIV-related deaths in youth and adolescents (aged 10-24) from 2005 to 2012 highlights the need to improve HIV treatment and care in this population, including...
The effect of early initiation of antiretroviral therapy in TB/HIV coinfected patients: A systematic review and meta-analysis
BACKGROUND: The importance of early initiation of antiretroviral therapy (ART) for tuberculosis (TB) and HIV coinfected patients is controversial. We conducted a systematic review and meta-analysis to assess the effect...
Contemporary issues on the epidemiology and antiretroviral adherence of HIV-infected adolescents in sub-Saharan Africa: A narrative review
INTRODUCTION: Adolescents are a unique and sometimes neglected group in the planning of healthcare services. This is the case in many parts of sub-Saharan Africa, where more than eight out...
The HIV care cascade: A systematic review of data sources, methodology and comparability
INTRODUCTION: The cascade of HIV diagnosis, care and treatment (HIV care cascade) is increasingly used to direct and evaluate interventions to increase population antiretroviral therapy (ART) coverage, a key component...
Is there scope for cost savings and efficiency gains in HIV services? A systematic review of the evidence from low- and middle-income countries
OBJECTIVE: To synthesize the data available–on costs, efficiency and economies of scale and scope–for the six basic programmes of the UNAIDS Strategic Investment Framework, to inform those planning the scale-up...
Post-HAART outcomes in pediatric populations: Comparison of resource-limited and developed countries
CONTEXT: No formal comparison has been made between the pediatric post-highly active antiretroviral therapy (HAART) outcomes of resource-limited and developed countries. OBJECTIVE: To systematically quantify and compare major baseline characteristics...
Antiretroviral adherence interventions: A review of current literature and ongoing studies
Adherence has proven to be Achilles’ heel of antiretroviral therapy. To achieve the nearly perfect adherence apparently necessary for optimal effects, individuals often require assistance. In this review, we examine...
Novel interventions for HIV self-management in African American women: A systematic review of mHealth interventions.
The purpose of this systematic review was to assess the quality of interventions using mobile health (mHealth) technology being developed for and trialed with HIV-infected African American (AA) women. We...
Efficacy of antiretroviral therapy programs in resource-poor settings: A meta-analysis of the published literature
Background. Despite the advent of effective combination antiretroviral drug therapy (ART) for the treatment of human immunodeficiency virus (HIV) infection, many doubt the feasibility of ART treatment programs in resource-poor...
