Category Archives: Treatment
A systematic review of treatment fatigue among HIV-infected patients prescribed antiretroviral therapy
HIV treatment requires lifelong adherence to medication regimens that comprise inconvenient scheduling, adverse side effects, and lifestyle changes. Antiretroviral adherence and treatment fatigue have been inextricably linked. Adherence in HIV-infected...
Effectiveness and safety of rilpivirine, a non-nucleoside reverse transcriptase inhibitor, in treatment-naive adults infected with HIV-1: A meta-analysis
Objective: The aim of this study was to determine the effectiveness and safety of rilpivirine in treatment-naive adults infected with HIV-1. Methods: We ran duplicate searches of multiple databases and...
Effect of rapid HIV testing on HIV incidence and services in populations at high risk for HIV exposure: An equity-focused systematic review
OBJECTIVE: To assess the effects of rapid voluntary counselling and testing (VCT) for HIV on HIV incidence and uptake of HIV/AIDS services in people at high risk for HIV exposure....
Elevated homocysteine levels in human immunodeficiency virus-infected patients under antiretroviral therapy: A meta-analysis
AIM: To evaluate the association between the levels of homocysteine (Hcy), folate, vitamin B12 in human immunodeficiency virus (HIV)-infected patients who were treated with antiretroviral therapy (ART) or not treated...
Assessment of the impact of cotrimoxazole prophylaxis on key outcomes among HIV-infected adults in low- and middle-income countries: A systematic review
BACKGROUND: Cotrimoxazole (CTX) prophylaxis is among the key interventions provided to HIV-infected individuals in resource-limited settings. We conducted a systematic review of the available evidence. METHODS: MEDLINE, Embase, Global Health,...
The effect of early initiation of antiretroviral therapy in TB/HIV coinfected patients: A systematic review and meta-analysis
BACKGROUND: The importance of early initiation of antiretroviral therapy (ART) for tuberculosis (TB) and HIV coinfected patients is controversial. We conducted a systematic review and meta-analysis to assess the effect...
Contemporary issues on the epidemiology and antiretroviral adherence of HIV-infected adolescents in sub-Saharan Africa: A narrative review
INTRODUCTION: Adolescents are a unique and sometimes neglected group in the planning of healthcare services. This is the case in many parts of sub-Saharan Africa, where more than eight out...
The HIV care cascade: A systematic review of data sources, methodology and comparability
INTRODUCTION: The cascade of HIV diagnosis, care and treatment (HIV care cascade) is increasingly used to direct and evaluate interventions to increase population antiretroviral therapy (ART) coverage, a key component...
Is there scope for cost savings and efficiency gains in HIV services? A systematic review of the evidence from low- and middle-income countries
OBJECTIVE: To synthesize the data available–on costs, efficiency and economies of scale and scope–for the six basic programmes of the UNAIDS Strategic Investment Framework, to inform those planning the scale-up...
Discontinuation of tenofovir disoproxil fumarate for presumed renal adverse events in treatment-naïve HIV-1 patients: Meta-analysis of randomized clinical studies
Background: Safety and efficacy of tenofovir disoproxil fumarate (TDF) as a component of antiretroviral therapy (ART) have been demonstrated in clinical trials. TDF nephrotoxicity has been reported in both HIV-infected...
Global burden of transmitted HIV drug resistance and HIV-exposure categories: A systematic review and meta-analysis
OBJECTIVES: Our aim was to review the global disparities of transmitted HIV drug resistance (TDR) in antiretroviral-naive MSM, people who inject drugs (PWID) and heterosexual populations in both high-income and...
Systematic literature review and meta-analysis of renal function in human immunodeficiency virus (HIV)-infected patients treated with Atazanavir (ATV)-based regimens
Some HIV antiretroviral therapies (ART) have been associated with renal toxicities, which become of increasing concern as HIV-infected patients age and develop comorbidities. The objective of this study was to...
