Category Archives: Treatment
Implementation of antiretroviral therapy adherence interventions: A realist synthesis of evidence
AIM: This paper is a report of a synthesis of evidence on implementation of interventions to improve adherence to antiretroviral therapy. BACKGROUND: Evidence on efficacy must be supplemented with evidence...
Task shifting of HIV management from doctors to nurses in Africa: Clinical outcomes and evidence on nurse self-efficacy and job satisfaction
With 24% global disease burden and 3% global health workforce, the World Health Organization (WHO) designates the African region a critical workforce shortage area. Task shifting is a WHO-recommended strategy...
Role and outcomes of community health workers in HIV care in sub-Saharan Africa: A systematic review
Introduction: The provision of HIV treatment and care in sub-Saharan Africa faces multiple challenges, including weak health systems and attrition of trained health workers. One potential response to overcome these...
Nucleoside reverse transcriptase inhibitors in combination therapy for HIV patients: Systematic review and meta-analysis
Treatment guidelines recommend dual nucleoside reverse transcriptase inhibitors (NRTI ) as a part of combination antiretroviral therapy. The objective of this study was to assess the relative efficacy and toxicity...
Challenges, coping strategies, and recommendations related to the HIV services field in the HAART era: A systematic literature review of qualitative studies from the United States and Canada
Qualitative research methods have been utilized to study the nature of work in the HIV services field. Yet current literature lacks a Highly Active Anti-Retroviral Treatment (HAART) era compendium of...
Determinants of male involvement in maternal and child health services in sub-Saharan Africa: A review
INTRODUCTION: Male participation is a crucial component in the optimization of Maternal and Child Health (MCH) services. This is especially so where prevention strategies to decrease Mother-to-Child Transmission (MTCT) of...
Use of electronic reminder devices to improve adherence to antiretroviral therapy: A systematic review
Adherence to prescribed antiretroviral therapy (ART) is one of the strongest predictors of progression to AIDS and death among people living with HIV/AIDS. Incorrect or inconsistent adherence to ART compromises...
Treatment of chronic hepatitis C in haemophilic patients with interferon and ribavirin: A meta-analysis
BACKGROUND: Hepatitis C virus (HCV) infection is a major cause of morbidity and mortality among haemophilic patients who were treated with clotting factor concentrates before the availability of virus-inactivated factors...
Complementary and alternative medicine use among HIV-positive people: Research synthesis and implications for HIV care
Use of complementary and alternative medicine (CAM) is prevalent among HIV-positive individuals despite the success of antiretroviral treatments and limited evidence of CAM’s safety and efficacy. To characterize the potential...
Clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: A meta-analysis of randomized individual patient data
A meta-analysis of 8 randomized trials (1792 patients, 2947 patient-years of follow-up) showed that acyclovir (> or = 3200 mg/day) offered a significant survival benefit (P = .006 by log-rank...
