Category Archives: Treatment

Humanized PA14 (a monoclonal CCR5 antibody) for treatment of people with HIV infection

2014

BACKGROUND: PRO 140 (a humanized form of the PA14 antibody, a monoclonal CCR5 antibody) inhibits CCR5-tropic (R5) type 1 human immunodeficiency virus (HIV). This may be an effective new treatment...

Nystatin prophylaxis and treatment in severely immunodepressed patients

2002

BACKGROUND: Nystatin is sometimes used prophylactically in patients with severe immunodeficiency or in the treatment of fungal infection in such patients, although the effect seems to be equivocal. OBJECTIVES: To...

HIV, alcohol dependence, and the criminal justice system: A review and call for evidence-based treatment for released prisoners

2011

BACKGROUND: People with both HIV and alcohol use disorders (AUDs) are disproportionately concentrated within the U.S. criminal justice system; approximately one-quarter of all people with HIV cycle through the system...

Etravirine as a switching option for patients with HIV RNA suppression: A review of recent trials

2014

Unlike other nonnucleoside reverse transcriptase inhibitors, etravirine is only approved for use in treatment-experienced patients. In the DUET 1 and 2 trials, 1203 highly treatment-experienced patients were randomized to etravirine...

Sex differences in HIV outcomes in the highly active antiretroviral therapy era: A systematic review.

2014

Objective: To assess sex disparities in AIDS clinical and laboratory outcomes in the HAART era. Design: Systematic review of published literature on mortality, disease progression, and laboratory outcomes among persons...

Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection

2012

BACKGROUND: More than 34 million people are presently living with HIV infection. Antiretroviral therapy (ART) can help these people to live longer, healthier lives, but adherence to ART can be...

Workplace programmes for HIV and tuberculosis: A systematic review to support development of international guidelines for the health workforce

2013

The health service sector has a vital role to play in delivering human immunodeficiency virus (HIV) and tuberculosis (TB) prevention, treatment and care, yet evidence indicates that healthcare workers (HCWs)...

Acceptability of HIV self-testing: A systematic literature review

2013

BACKGROUND: The uptake of HIV testing and counselling services remains low in risk groups around the world. Fear of stigmatisation, discrimination and breach of confidentiality results in low service usage...

Minimizing resistance consequences after virologic failure on initial combination therapy: A systematic overview

2006

OBJECTIVE: To identify optimal first-line therapies based on the rate of virologic success (VS) and the preservation of future treatment options in antiretroviral therapy (ART)-naive subjects. DESIGN: Systematic overview of...

Global trends in antiretroviral resistance in treatment-naive individuals with HIV after rollout of antiretroviral treatment in resource-limited settings: A global collaborative study and meta-regression analysis

2012

BACKGROUND: The emergence and spread of high levels of HIV-1 drug resistance in resource-limited settings where combination antiretroviral treatment has been scaled up could compromise the effectiveness of national HIV...

Socioeconomic factors in adherence to HIV therapy in low- and middle-income countries

2013

It is not clear what effect socioeconomic factors have on adherence to antiretroviral therapy (ART) among patients in low- and middle-income countries. We performed a systematic review of the association...

Depression and HIV/AIDS treatment nonadherence: A review and meta-analysis

2011

We meta-analyzed the relationship between depression and HIV medication nonadherence to calculate the overall effect size and examine potential moderators. Overall, across 95 independent samples, depression was significantly (P <...

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