Category Archives: Treatment
Omega-3 fatty acids and hypertriglyceridemia in HIV-infected subjects on antiretroviral therapy: Systematic review and meta-analysis
PURPOSE: Antiretroviral therapy (ART) changed the course of AIDS. However, it has been associated with chronic metabolic complications including hypertriglyceridemia. The aim of this systematic review is to evaluate the...
Implementation of antiretroviral therapy adherence interventions: A realist synthesis of evidence
AIM: This paper is a report of a synthesis of evidence on implementation of interventions to improve adherence to antiretroviral therapy. BACKGROUND: Evidence on efficacy must be supplemented with evidence...
Task shifting of HIV management from doctors to nurses in Africa: Clinical outcomes and evidence on nurse self-efficacy and job satisfaction
With 24% global disease burden and 3% global health workforce, the World Health Organization (WHO) designates the African region a critical workforce shortage area. Task shifting is a WHO-recommended strategy...
Role and outcomes of community health workers in HIV care in sub-Saharan Africa: A systematic review
Introduction: The provision of HIV treatment and care in sub-Saharan Africa faces multiple challenges, including weak health systems and attrition of trained health workers. One potential response to overcome these...
Nucleoside reverse transcriptase inhibitors in combination therapy for HIV patients: Systematic review and meta-analysis
Treatment guidelines recommend dual nucleoside reverse transcriptase inhibitors (NRTI ) as a part of combination antiretroviral therapy. The objective of this study was to assess the relative efficacy and toxicity...
Neurocognitive impairment in HIV-1-infected adults in Sub-Saharan Africa: A systematic review and meta-analysis
OBJECTIVE: To estimate the burden of HIV neurocognitive impairment (NCI) among adult patients on and off antiretroviral therapy (ART) in Sub-Saharan Africa. METHODS: Estimates were derived from a random effects...
Suppression of HBV by tenofovir in HBV/HIV coinfected patients: A systematic review and meta-analysis.
BACKGROUND: Hepatitis B coinfection is common in HIV-positive individuals and as antiretroviral therapy has made death due to AIDS less common, hepatitis has become increasingly important. Several drugs are available...
A systematic review of pediatric adherence to antiretroviral therapy in low- and middle-income countries
BACKGROUND: Sustaining antiretroviral therapy (ART) adherence requires accurate, consistent monitoring, a particular challenge for low-income countries. The optimal strategy to measure pediatric adherence remains unclear. OBJECTIVE: To conduct a systematic...
Efficacy of influenza vaccination in HIV-positive patients: A systematic review and meta-analysis
BACKGROUND: International treatment guidelines recommend that HIV-positive patients be vaccinated for influenza annually. Evidence supporting this recommendation is limited. We assessed the efficacy of influenza vaccines in preventing influenza in...
Vertically acquired paediatric HIV infection: the challenges of providing comprehensive packages of care in resource-limited settings
The successes achieved in paediatric disease management in well-resourced countries in recent years highlight the vast divide between the care options, and ultimately survival, between developed and developing areas of...
