Category Archives: Treatment
Tipranavir: The first nonpeptidic protease inhibitor for the treatment of protease resistance
Background: Despite the availability of a growing number of potent antiretroviral agents, efforts to completely suppress viral replication in patients with HIV-1 infection are limited because of the increasing risk...
Limited benefit of antiretroviral resistance testing in treatment-experienced patients: A meta-analysis
OBJECTIVE: To estimate the effectiveness of resistance assessments based on viral sequencing (genotypic antiretroviral resistance testing, GART), phenotypic antiretroviral resistance testing (PART) or virtual PART (vPART) in the management of...
Antiretroviral therapy uptake, attrition, adherence and outcomes among HIV-infected female sex workers: A systematic review and meta-analysis.
PURPOSE: We aimed to characterize the antiretroviral therapy (ART) cascade among female sex workers (FSWs) globally. METHODS: We systematically searched PubMed, Embase and MEDLINE in March 2014 to identify studies...
Treatment outcomes after highly active antiretroviral therapy: A meta-analysis of randomised controlled trials
This systematic review summarises the evidence for treatment efficacy and tolerability of highly active antiretroviral therapies containing two nucleoside reverse transcriptase inhibitors (NRTI) with a protease inhibitor (PI), compared with...
Integrating prevention of mother-to-child HIV transmission programs to improve uptake: A systematic review
Background: We performed a systematic review to assess the effect of integrated perinatal prevention of mother-to-child transmission of HIV interventions compared to non- or partially integrated services on the uptake...
Modeling the cost-effectiveness of HIV treatment: how to buy the most ‘health’ when resources are limited
PURPOSE OF REVIEW: To summarize recent cost-effectiveness analyses (CEAs) that evaluate optimal treatment strategies for persons living with HIV/AIDS (PLWHA). RECENT FINDINGS: Efforts to attain universal coverage of current treatment...
A systematic review of the literature on self-management interventions and discussion of their potential relevance for people living with HIV in sub-Saharan Africa
OBJECTIVE: This study systematically reviews the literature on self-management interventions provided by health care teams, community partners, patients and families and discusses the potential relevance of these interventions for people...
Correlates and predictors of adherence to highly active antiretroviral therapy: Overview of published literature
Knowledge of factors associated with medication adherence could help HIV clinicians to target persons in need of intervention, design these interventions, and help researchers to plan studies of adherence. This...
Mental health of HIV-seropositive women during pregnancy and postpartum period: A comprehensive literature review
With growing numbers of HIV-seropositive (HIV+) women of child-bearing age and increased access to effective clinical protocols for preventing mother-to-child transmission (MTCT) of HIV, mental health-related factors have become increasingly...
Efficacy of new antiretroviral drugs in treatment-experienced HIV-infected patients: A systematic review and meta-analysis of recent randomized controlled trials
OBJECTIVES: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the overall efficacy of new antiretroviral drugs, as well as the factors associated with increased...
Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: A systematic review and pooled analysis
CONTEXT: Presence of low-frequency, or minority, human immunodeficiency virus type 1 (HIV-1) drug resistance mutations may adversely affect response to antiretroviral treatment (ART), but evidence regarding the effects of such...
