Category Archives: Treatment
Treatment of active tuberculosis in HIV-coinfected patients: A systematic review and meta-analysis
BACKGROUND: Patients with human immunodeficiency virus (HIV) infection and tuberculosis have an increased risk of death, treatment failure, and relapse. METHODS: A systematic review and meta-analysis of randomized, controlled trials...
Effects of HIV antiretrovirals on the pharmacokinetics of hormonal contraceptives
OBJECTIVES: To review available information on pharmacokinetic effects of HIV antiretrovirals on hormonal contraceptives. METHODS: A PubMed search was conducted from 1964 to 2006 using each antiretroviral generic name and...
Economic and quality of life outcomes of antiretroviral therapy for HIV/AIDS in developing countries: A systematic literature review
The impacts of antiretroviral therapy (ART) on quality of life, mental health, labor productivity, and economic wellbeing for people living with HIV/AIDS in developing countries are only beginning to be...
Nonnucleoside reverse transcriptase inhibitor resistance and the role of the second-generation agents
OBJECTIVE: To review the current state of nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance, discuss the promising role of second-generation NNRTIs, and provide insight into their clinical utility. DATA SOURCES: Articles...
Contraception for the HIV-positive woman: A review of interactions between hormonal contraception and antiretroviral therapy
Background. Preventing unintended pregnancy in HIV-positive women can significantly reduce maternal-to-child HIV transmission as well as improve the woman’s overall health. Hormonal contraceptives are safe and effective means to avoid...
Bone mineral density in HIV-infected women taking antiretroviral therapy: A systematic review
There is a high prevalence of osteoporosis in HIV-infected patients. Initially described in HIV-positive men, studies have also demonstrated a high prevalence of osteoporosis in HIV-infected women. It would appear...
The management of dyslipidaemias in antiretroviral-treated HIV infection: A systematic review
OBJECTIVES: The aim of the study was to assess the currently available evidence concerning the management of dyslipidaemias in HIV-infected individuals treated with antiretroviral therapy. METHODS: Randomized trials, published within...
Clinical efficacy of antiretroviral combination therapy based on protease inhibitors or non-nucleoside analogue reverse transcriptase inhibitors: Indirect comparison of controlled trials
Objective: To compare the clinical efficacy of triple antiretroviral regimens based on protease inhibitors and non-nucleoside analogue reverse transcriptase inhibitors (NNRTIs) in adults positive for antibodies to HIV-1. Design: Systematic...
Recreational use of sildenafil by HIV-positive and -negative homosexual/bisexual males
OBJECTIVE: To conduct an epidemiologic review of sildenafil in homosexual and bisexual males focusing on concurrent use with club drugs and/or antiretroviral medications. DATA SOURCES: A search of MEDLINE was...
Antiretroviral adherence interventions in Southern Africa: Implications for using HIV treatments for prevention
There is concern that the expansion of ART (antiretroviral treatment) programmes to incorporate the use of treatment as prevention (TasP) may be associated with low levels of adherence and retention...
Antiretroviral therapy for children in resource-limited settings: Current regimens and the role of newer agents
WHO antiretroviral treatment guidelines for HIV-infected children have influenced the design of treatment programmes in resource-limited settings. This review analyses the latest WHO first- and second-line regimen recommendations. The recommendation...
