Category Archives: Treatment
Optimal timing for antiretroviral therapy initiation in patients with HIV infection and concurrent cryptococcal meningitis
BACKGROUND: Currently, initiation of antiretroviral therapy (ART) in most patients with human immunodeficiency virus (HIV) infection is based on the CD4-positive-t-lymphocyte count. However, the point during the course of HIV...
The cost of treatment and care for people living with HIV infection: Implications of published studies, 1999-2008
Purpose of review: Increasing number of people living with HIV (PLHIV) will require expanded access to health services. Countries need robust and contemporary strategic information on the cost of care...
HIV-1 and intestinal helminth review update: Updating a Cochrane Review and building the case for treatment and has the time come to test and treat?
Intestinal helminth infection activates and dysregulates the immune system and impacts the host’s capacity to respond to illness. Such neglected tropical infections exact the greatest burden on resource-limited settings and...
Clinical trials of interactive computerized patient education: Implications for family practice
A systematic review of randomized clinical trials was conducted to evaluate the acceptability and usefulness of computerized patient education interventions. The Columbia Registry, MEDLINE, Health, BIOSIS, and CINAHL bibliographic databases...
Interactions between protease inhibitors and acid-reducing agents: A systematic review
OBJECTIVE: The purpose of this article is to provide a systematic review of the available pharmacokinetic and clinical data on drug interactions between protease inhibitors (PIs) and acid-reducing agents, and...
Motivational interviewing as a behavioral intervention to increase HAART adherence in patients who are HIV-positive: A systematic review of the literature
As HIV infection rates continue to rise, more and more people are faced with a complex, life-altering highly active antiretroviral therapy (HAART) regimen. With some researchers reporting as few as...
Clinical trials in sub-Saharan Africa and established standards of care: A systematic review of HIV, tuberculosis, and malaria trials
Context: The minimum standard of care required for participants in clinical trials conducted in resource-poor settings is a matter of controversy; international documents offer contradictory guidance. Objective: To determine whether...
Linking women who test HIV-positive in pregnancy-related services to long-term HIV care and treatment services: A systematic review
Objectives To quantify attrition between women testing HIV-positive in pregnancy-related services and accessing long-term HIV care and treatment services in low- or middle-income countries and to explore the reasons underlying...
Lessons learned from use of highly active antiretroviral therapy in Africa
BACKGROUND: Because antiretrovirals are becoming increasingly available in developing countries, we reviewed the findings of studies that have documented highly active antiretroviral therapy (HAART) use in Africa to identify lessons...
