Category Archives: Treatment
Equity and efficiency in scaling up access to HIV-related interventions in resource-limited settings
Purpose of review: The present review focuses on empirical studies examining equity and efficiency in scaling up access to HIV treatment in resource-limited settings. Key themes from reviewed papers are...
The utility of therapeutic drug monitoring for ribavirin in patients with chronic hepatitis C – A critical review
OBJECTIVE: To evaluate the utility of therapeutic drug monitoring (TDM) for ribavirin in chronic hepatitis C. DATA SOURCES: Literature searches were conducted through PubMed (1949-June 2009), EMBASE (1980-June 2009), BIOSIS...
A meta-analysis of adherence to antiretroviral therapy and virologic responses in HIV-infected children, adolescents, and young adults
The relationship between adherence to antiretroviral therapy (ART) and virologic outcomes in HIV+ children, adolescents, and young adults has been notably understudied, with much of the extant research focused on...
Antiviral treatment for chronic hepatitis C in patients with human immunodeficiency virus
BACKGROUND: Antiviral treatment for chronic hepatitis C may be less effective if patients are co-infected with human immunodeficiency virus (HIV). OBJECTIVES: To assess the benefits and harms of antiviral treatment...
A systematic review comparing antiretroviral adherence descriptive and intervention studies conducted in the USA
We examined the extent to which studies aimed at testing interventions to improve antiretroviral adherence have targeted the facilitators of and barriers known to affect adherence. Of the 88 reports...
Cotrimoxazole for prophylaxis or treatment of opportunistic infections of HIV/AIDS in patients with previous history of hypersensitivity to cotrimoxazole
BACKGROUND: Opportunistic infections continue to cause a significant amount of morbidity and mortality worldwide in patients infected with HIV. Trimethoprim-sulfamethoxazole (cotrimoxazole) is used in the treatment and prophylaxis of several...
Unstructured treatment interruption of antiretroviral therapy in clinical practice: A systematic review
Objective To characterize the frequency, reasons, risk factors, and consequences of unstructured anti-retroviral treatment interruptions. Method Systematic review. Results Seventy studies were included. The median proportion of patients interrupting treatment...
Efficacy of selected treatments of HIV wasting: A systematic review and meta-analysis
PURPOSE: To assess the efficacy of recombinant human growth hormone (rhGH), testosterone, and anabolic steroids in the treatment of HIV wasting. METHODS: A systematic review and meta-analysis of studies published...
Diarrhea associated with lopinavir/ritonavir-based therapy: Results of a meta-analysis of 1469 HIV-1-infected participants
BACKGROUND: Antiretroviral therapy is associated with adverse events (AEs). The most frequently reported AE associated with lopinavir/ritonavir (LPV/r) containing regimens is diarrhea. The objective of this meta-analysis is to describe...
Redressing the epidemics of opioid overdose and HIV among people who inject drugs in Central Asia: The need for a syndemic approach
BACKGROUND: Accumulating evidence suggests that opioid overdose and HIV infection are burgeoning intertwined epidemics among people who inject drugs (PWID) in Central Asia. To date, however, research on overdose and...
Stable bone density in HAART-treated individuals with HIV: A meta-analysis
Context: Longitudinal studies of bone mineral density (BMD) in HIV have reported conflicting results. Objective: We investigated whether temporal changes in BMD differ by highly active antiretroviral therapy (HAART) status...
