Category Archives: Treatment
Fixed-dose combinations improve medication compliance: A meta-analysis
BACKGROUND: Compliance with treatment is a sine qua non for successful treatment of chronic conditions like hypertension. Fixed-dose combinations are designed to simplify the medication regimen and potentially improve compliance....
Emergence of drug resistance in HIV type 1-infected patients after receipt of first-line highly active antiretroviral therapy: A systematic review of clinical trials
Background. Resistance to antiretroviral combination therapy is associated with increased mortality. Understanding the relative risks of emerging resistance to first-line therapy is of importance for both resource-rich and resource-poor settings....
Meta-analysis: Increased mortality associated with hepatitis C in HIV-infected persons is unrelated to HIV disease progression
Background: It is unclear whether coinfection with hepatitis C virus (HCV) increases mortality in patients with human immunodeficiency virus (HIV) infection during the era of highly active antiretroviral therapy (HAART)....
Rates of emergence of HIV drug resistance in resource-limited settings: A systematic review
BACKGROUND: The increasing availability of antiretroviral therapy (ART) has improved survival and quality of life for many infected with HIV, but can also engender drug resistance. This review summarizes the...
The effectiveness of HIV partner counseling and referral services in increasing identification of HIV-positive individuals: A systematic review
Partner counseling and referral services (PCRS) are part of the spectrum of care for HIV-positive people and their sexual or needle-sharing partners. Referral includes notifying partners of exposure, after which...
Effectiveness of protease inhibitor monotherapy versus combination antiretroviral maintenance therapy: A meta-analysis
BACKGROUND: The unparalleled success of combination antiretroviral therapy (cART) is based on the combination of three drugs from two classes. There is insufficient evidence whether simplification to ritonavir boosted protease...
A narrative review of research on the effects of physical activity on people living with HIV and opportunities for health promotion in disadvantaged settings
The article explores different types and effects of physical activity for people living with HIV. Considering the lack of studies done in African contexts and the disparity between research settings...
Self-reported adherence to antiretroviral therapy for HIV-1 infection and virologic treatment response: A meta-analysis
Background: Adherence to highly active antiretroviral therapy (HAART) for HIV-1 infection is essential for plasma HIV-1 RNA suppression. Self-report is the most frequently used measure of adherence to HAART, but...
The impact of community mobilisation on HIV prevention in middle and low income countries: A systematic review and critique.
While community mobilisation (CM) is increasingly advocated for HIV prevention, its impact on measurable outcomes has not been established. We performed a systematic review of the impact of CM within...
Highly active antiretroviral therapy and sexual risk behavior: A meta-analytic review
Context: Evidence suggests that since highly active antiretroviral therapy (HAART) became available, the prevalence of unprotected sex and the incidence of sexually transmitted infections (STIs) have increased. Objective: To conduct...
