Category Archives: Treatment
Mapping the gut microbiota composition in the context of Raltegravir, dolutegravir, and bictegravir—A scoping review
(1) Background: Second-generation integrase strand transfer inhibitors (INSTIs) are now the preferred first-line therapies for human immunodeficiency virus (HIV). However, concerns regarding their side effects, such as weight gain and...
Association between baseline HIV-1 DNA levels and clinical outcomes in people living with HIV: A meta-analysis of cohort studies
This systematic review and meta-analysis evaluated the effect of digital communication tools (e.g., text message reminders) on improving daily oral HIV pre-exposure prophylaxis (PrEP) adherence. Searching PubMed, Embase, Web of...
Transition From adolescent to adult care for young people living with HIV: A systematic review of needs, barriers, and interventions
Young people living with HIV (YPLHIV) aged 15-24 years represent over 25% of new HIV infections globally. They face significant challenges in transitioning from pediatric to adult care. Despite guidelines...
Assessing the impact of digital communication tools on oral PrEP adherence: A systematic review and meta-analysis
This systematic review and meta-analysis evaluated the effect of digital communication tools (e.g., text message reminders) on improving daily oral HIV pre-exposure prophylaxis (PrEP) adherence. Searching PubMed, Embase, Web of...
Magnitude and characteristics of unsuppressed HIV viral load in children and adolescents on antiretroviral therapy in sub-Saharan Africa: A systematic review and meta-analysis
Background: HIV/AIDS remains a major health issue in sub-Saharan Africa, especially among children and adolescents, with a substantial proportion of people with HIV having unsuppressed viral loads despite the availability of...
Cannabis use and HIV among Black sexually minoritized men: A systematic review and narrative analysis
Objective: We conducted a systematic review evaluating the extant literature examining the impacts of cannabis use on HIV-related outcomes among Black sexual minoritized men (BSMM). Design: A systematic review. Methods: We conducted a...
Comparative safety of B/F/TAF versus other antiretroviral therapy regimens for treatment-naïve people with HIV-1: A systematic literature review and network meta-analysis
Aim: Bictegravir, emtricitabine and tenofovir alafenamide (B/F/TAF) is a single-tablet regimen approved for the treatment of HIV-1 in treatment-naive (TN) and virologically suppressed people with HIV-1 (PWH). While the efficacy of...
The effectiveness of monetary incentives in improving viral suppression, treatment adherence, and retention in care among the general population of people living with HIV: A systematic review and meta-analysis
Background Achieving and maintaining viral suppression and optimal adherence to antiretroviral therapy are crucial for improving health outcomes in general population of people living with HIV. This study aimed to...
The prevalence of dyslipidemia and its correlation with anti-retroviral therapy among people living with HIV in China: A systematic review and meta-analysis
Background Dyslipidemia, a risk factor of cardiovascular diseases, was a long-term adverse event of anti-retroviral drugs. Efavirenz (EFV) and lopinavir/ritonavir (LPV/r) were recommended and the widely used antiretroviral drugs while...
A meta-analysis of prevalence and moderating factors of malnutrition among people living with HIV across countries
Malnutrition is a critical issue for people living with HIV (PLWH), affecting their immune function, health outcomes, and response to antiretroviral therapy. This meta-analysis assessed the prevalence of malnutrition among...
The Tryptophan-Kynurenine pathway in people living with HIV: A systematic review
Purpose: HIV-1 disrupts the metabolic profile of people living with HIV (PLWH), including the Tryptophan-Kynurenine (Trp-Kyn) pathway, linked to disease outcomes and comorbidities. Despite numerous studies, consensus on key dysregulated metabolites...
Effects of nutritional interventions on nutritional and immunological status and adherence to antiretroviral treatment among adults living with HIV in low- and middle-income countries: Systematic review and meta-analysis
Background HIV/AIDS may cause malnutrition, both directly and indirectly, through common infections. This systematic review and meta-analysis aim to evaluate the effects of nutritional interventions on nutritional status, immunological status,...
