Category Archives: Treatment
Burden of malaria-HIV coinfection and associated adverse outcomes in Ethiopia: A systematic review and meta-analysis
Background The co-occurrence of malaria and HIV represents a significant health crisis in sub-Saharan Africa, particularly in Ethiopia, where both diseases are prevalent. This synergistic burden aggravates health inequalities, strains...
Incidence and predictors of mortality among adults on antiretroviral therapy in Ethiopia: A systematic review and meta-analysis
BACKGROUND: Despite the United Nations’ plan to end Human Immunodeficiency Virus (HIV) as a public health concern by 2030, it remains a significant issue in low-income countries, including Ethiopia. Currently,...
Organization and integration of care in the HIV-non-communicable disease syndemic: A rapid scoping review
Advances in antiretroviral therapy have transformed infection with HIV into a manageable chronic disease, increasing the survival of people living with HIV, who are also undergoing a demographic aging process...
Global mental health disparities among transgender women and transfeminine people living with HIV: A systematic review and meta-analysis of 63 studies
Background Transgender women and transfeminine people face a disproportionate burden of mental health conditions driven by stigma, discrimination, and structural inequities, with additional psychosocial challenges related to HIV diagnosis and...
Broadly neutralizing antibodies for HIV therapy in clinical trials: A systematic review
Background: Lifelong daily antiretroviral therapy (ART) effectively suppresses human immunodeficiency virus type 1 (HIV-1) replication but does not eradicate the virus, underscoring the urgent need for long-acting antivirals and functional cure...
Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications
Dolutegravir underpins modern first- and second-line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the...
Prevalence and risk of cardiovascular events among people living with HIV: A meta-analysis
BACKGROUND: People living with HIV (PLWH) have increased cardiovascular risk, but the contribution of HIV-related factors to all-cause cardiovascular events remains unclear. We assessed the prevalence and determinants of cardiovascular...
Retention in care among women with HIV: A systematic review of treatment continuity during pregnancy and postpartum
Introduction Pregnant women with HIV are at risk of reduced engagement in HIV care during pregnancy and postpartum. Retention in care, defined as continuous engagement in HIV-related treatment and follow-up,...
Guidance on the clinical management of HIV-1 persistent low-level viraemia on antiretroviral treatment: A scoping review and an international Delphi consensus
Despite the success of antiretroviral therapy, a subset of people with HIV experience low-level viraemia (LLV), a challenging condition with inconsistent definitions and management across settings. We conducted a scoping...
Barriers and facilitators of isoniazid preventive therapy implementation among people living with HIV in Nigeria: A scoping review of the literature
BACKGROUND: Implementation of Isoniazid Preventive Therapy (IPT) among People Living with HIV (PLHIV) continues to be a significant challenge, and there is a shortage of effective interventions. This scoping review...
Models of care for women living with HIV in Europe: A scoping review
INTRODUCTION: With the widespread availability of antiretroviral therapy, human immunodeficiency virus (HIV) has become a chronic condition requiring long-term, integrated care. Women with HIV experience distinct clinical, reproductive, and psychosocial...
