Category Archives: Treatment

Prevalence of transmitted resistance to non-nucleoside reverse transcriptase inhibitors in European and North American countries over 20 years: An updated meta-analysis

2021

The prevalence of transmitted non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance around the world has been estimated up to 2010. Treatment recommendations have since evolved from NNRTIs to integrase strand inhibitors...

Human immunodeficiency virus-positive women’s perspectives on breastfeeding with antiretrovirals: A qualitative evidence synthesis

2021

Human immunodeficiency virus (HIV)-positive women can breastfeed with minimal risk of mother-to-child transmission if taking antiretrovirals. Guidelines surrounding infant feeding for HIV-positive women have evolved several times over the last...

A systematic review of magnetic resonance imaging studies in perinatally HIV-infected individuals

2021

Over the past few years, neuroimaging studies have been performed in young adults with perinatally acquired HIV (PHIV) to study the impact of HIV infection on the central nervous system...

Cardiovascular risks associated with protease inhibitors for the treatment of HIV

2021

Introduction: Cumulative use of some first-generation protease inhibitors has been associated with higher rates of dyslipidemia and increased risk of cardiovascular disease. The protease inhibitors most commonly in use are...

Association between frailty phenotype, quantification of plasma HIV-1 RNA, CD4 cell count and HAART in HIV-positive subjects: A systematic review and meta-analysis of observational studies

2021

HIV infection causes a constant activation of the immune system and contributes to an enhanced systemic pro-inflammatory cytokine milieu, which has been associated with premature aging and frailty. We performed...

Impact of nonadherence to antiretroviral therapy (ART) on population-level health outcomes

2021

Several studies analyze overall healthcare costs, pharmacy costs, and cost savings among people living with HIV relative to level of ART adherence. Generally, adherence to ART appears to predict levels...

Impact of universal coverage for antiretroviral therapy (ART) on health outcomes

2021

As of 2017, the annual cost of single-tablet antiretrovirals (ART) in Ontario was estimated to be CAD 15,552 according to the Ontario Drug Benefit Formulary. Universal, no-cost ART for all...

Cost-Effectiveness of antiretroviral therapy: A systematic review

2020

BACKGROUND: The mobilization of resources to prevent and treat human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) is unparalleled in the history of public health. The uptake of antiretroviral...

Effectiveness of naltrexone treatment for alcohol use disorders in HIV: A systematic review

2021

BACKGROUND: Because alcohol use disorders (AUDs) in patients living with HIV/AIDS are associated with a reduction in therapeutic outcomes and increases the risk of morbidity/mortality, finding an appropriate pharmacotherapy treatment...

Digital health for sexually transmitted infection and HIV services: A global scoping review

2021

PURPOSE OF REVIEW: The current study aimed to review how digital health has been used for sexually transmitted infection (STI)/HIV prevention, testing, and treatment. RECENT FINDINGS: A scoping review was...

What do HIV-positive drug users’ experiences tell us about their antiretroviral medication-taking? An international integrated literature review

2021

BACKGROUND AND AIMS: HIV-positive drug users’ poor adherence to antiretroviral regimens can pose a significant and negative impact on individual and global health. This review aims to identify knowledge gaps...

Strategies for retention of heterosexual men in HIV care in sub-Saharan Africa: A systematic review

2021

Expansion of Antiretroviral Therapy (ART) programs in sub-Saharan Africa (SSA) has increased the number of people accessing treatment. However, the number of males accessing and being retained along the human...

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