Category Archives: Treatment
ART initiations following community-based distribution of HIV self-tests: Meta-analysis and meta-regression of STAR Initiative data
INTRODUCTION: Measuring linkage after community-based testing, particularly HIV self-testing (HIVST), is challenging. Here, we use data from studies of community-based HIVST distribution, conducted within the STAR Initiative, to assess initiation...
Cerebrospinal fluid immune markers and HIV-associated neurocognitive impairments: A systematic review
HIV-1 is responsible for the development of a spectrum of cognitive impairments known as HIV-associated neurocognitive disorder (HAND). In the era of antiretroviral therapy (ART), HAND remains prevalent in people...
Association of HIV infection and antiretroviral therapy With arterial stiffness: A systematic review and meta-analysis
Incidence of cardiovascular disease in people living with HIV has increased as overall survival has improved because of combination antiretroviral therapy (cART). Arterial stiffness is a composite indicator of cardiovascular...
Human immunodeficiency virus-positive women’s perspectives on breastfeeding with antiretrovirals: A qualitative evidence synthesis
Human immunodeficiency virus (HIV)-positive women can breastfeed with minimal risk of mother-to-child transmission if taking antiretrovirals. Guidelines surrounding infant feeding for HIV-positive women have evolved several times over the last...
Cardiovascular risks associated with protease inhibitors for the treatment of HIV
Introduction: Cumulative use of some first-generation protease inhibitors has been associated with higher rates of dyslipidemia and increased risk of cardiovascular disease. The protease inhibitors most commonly in use are...
Association between frailty phenotype, quantification of plasma HIV-1 RNA, CD4 cell count and HAART in HIV-positive subjects: A systematic review and meta-analysis of observational studies
HIV infection causes a constant activation of the immune system and contributes to an enhanced systemic pro-inflammatory cytokine milieu, which has been associated with premature aging and frailty. We performed...
Prevalence of transmitted resistance to non-nucleoside reverse transcriptase inhibitors in European and North American countries over 20 years: An updated meta-analysis
The prevalence of transmitted non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance around the world has been estimated up to 2010. Treatment recommendations have since evolved from NNRTIs to integrase strand inhibitors...
Effectiveness of naltrexone treatment for alcohol use disorders in HIV: A systematic review
BACKGROUND: Because alcohol use disorders (AUDs) in patients living with HIV/AIDS are associated with a reduction in therapeutic outcomes and increases the risk of morbidity/mortality, finding an appropriate pharmacotherapy treatment...