Category Archives: Treatment
Comparative safety of B/F/TAF versus other antiretroviral therapy regimens for treatment-experienced people with HIV-1: A systematic literature review and network meta-analysis
Aim: With modern antiretroviral therapy (ART), HIV-1 has now become a manageable chronic condition. Among treatment-experienced (TE) people with HIV-1 (PWH), ART regimens can influence metabolic and renal outcomes and...
Perinatal HIV in Europe: Clinical advances and psychosocial challenges—A scoping review
Despite significant biomedical advances in the prevention of mother-to-child transmission (MTCT) of HIV, residual transmission and suboptimal maternal outcomes persist across Europe. The challenge is no longer primarily virological but...
Efficacy and safety of doravirine/islatravir for HIV-1: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials
Background: The combination of doravirine and islatravir (DOR/ISL) is a novel two-drug regimen for HIV-1. Early development faced challenges due to dose-dependent immunological signals. We aimed to synthesize the evidence on...
Empowering women living with HIV through partner-based interventions: A scoping review
Spouses and partners play a crucial role in the well-being of women living with HIV (WLWH), especially in family-oriented cultures. This scoping review examined partner-inclusive interventions to strengthen support systems...
The association between food insecurity and adverse health outcomes in adults: An umbrella review of systematic reviews and meta-analyses
Context An association of food insecurity (FI) with adverse health outcomes (AHOs) has been reported; however, the evidence in this context is still inconclusive. Objective The certainty and validity of...
Mpox clinical outcomes in people with and without HIV treated with tecovirimat: A systematic review
Mpox poses heightened risks for immunocompromised individuals, particularly people with HIV (PWH), yet evidence on clinical outcomes and antiviral treatment remains limited. We conducted a systematic review in accordance with...
Guidance on the clinical management of HIV-1 persistent low-level viraemia on antiretroviral treatment: A scoping review and an international Delphi consensus
Despite the success of antiretroviral therapy, a subset of people with HIV experience low-level viraemia (LLV), a challenging condition with inconsistent definitions and management across settings. We conducted a scoping...
Understanding the implementation of patient navigation for adults living with HIV: A scoping review of components, equity considerations and lessons learned
Background People living with HIV navigate complex medical and social challenges that impact engagement in care, including stigma, poverty and systemic inequities. Patient navigation has emerged as a promising approach...
Patients’ perspectives on medication adherence feedback interventions for managing long-term medications: A systematic review of qualitative evidence
INTRODUCTION: Optimising medication usage is a worldwide challenge. While numerous feedback interventions have been developed to address this issue, understanding patients’ perspectives on the use of such interventions to optimise...
International guidelines for the management of healthcare workers living with HIV: A systematic comparative review
BACKGROUND: Despite strong evidence that sustained HIV viral suppression eliminates transmission risk (“undetectable equals untransmittable”, U=U), national approaches to managing healthcare workers (HCWs) living with HIV remain heterogeneous. Because such...
Implementation of point of care HIV viral load monitoring for people living with HIV in low- and middle-income countries: A systematic review on implementation research outcomes
BACKGROUND: Viral load monitoring has rapidly increased among people living with HIV(PLHIV) in low- and middle-income countries (LMICs), resulting in an increased laboratory workload. The use of innovative Point of...
