Category Archives: Treatment
Discontinuation, suboptimal adherence, and reinitiation of oral HIV pre-exposure prophylaxis: A global systematic review and meta-analysis
Background: Poor adherence to oral HIV pre-exposure prophylaxis (PrEP) diminishes its clinical and public health benefits. This study synthesises evidence regarding discontinuation, adherence, and reinitiation of PrEP among geographically diverse PrEP...
Effects of different integrase strand transfer inhibitors on body weight in patients with HIV/AIDS: A network meta-analysis
Background: Global antiretroviral therapy has entered a new era. Integrase strand transfer inhibitor (INSTI) has become the first choice in acquired immunodeficiency syndrome (AIDS) treatment. Because INSTI has high antiviral efficacy,...
Adherence to pre-exposure prophylaxis in adolescents and young adults: A systematic review and meta-analysis
This meta-analysis synthesized the proportion of adolescents and young adults (AYAs) who are adherent to pre-exposure prophylaxis (PrEP) and factors moderating adherence. A systematic search was conducted of studies published...
Impact of antiretroviral therapy on kidney disease in HIV infected individuals—A qualitative systematic review
Kidney disease is the fourth most common cause of non-AIDS-related mortality in people living with HIV. Combination antiretroviral therapy (cART) remains the cornerstone of treatment. However, little is known about...
Interventions to improve early retention of patients in antiretroviral therapy programmes in sub-Saharan Africa: A systematic review
BACKGROUND: Several interventions to improve long term retention (12 months and above) on treatment have been rigorously evaluated in Sub-Saharan Africa (SSA). However, research on interventions to improve retention of...
Impact of supervised aerobic exercise on clinical physiological and mental parameters of people living with HIV: A systematic review and meta-analyses of randomized controlled trials
Background: The benefits derived from supervised aerobic exercise in people living with human immunofeficiency virus- HIV (PLWH) have not yet been clearly identified.Objective: To evaluate the impact of supervised aerobic exercise on...
Traditional Chinese medicine for HIV-associated acute herpes zoster: A systematic review and meta-analysis of randomized trials
Background: Herpes zoster (HZ) is a common infection in individuals with acquired immunodeficiency syndrome (AIDS) patients. Traditional Chinese medicine (TCM) has been used widely in clinical practice for HZ, which remains...
Influence of combination antiretroviral therapy on HIV-1 serological responses and their implications: A systematic review and meta-analysis
We aimed to analyze HIV-1 seroreversion caused by combination antiretroviral therapy (cART) and to explore antibody levels of anti-HIV-1 as an alternative biomarker of HIV-1 reservoir. We searched PubMed, Embase,...
Perinatal outcomes in women living with HIV-1 and receiving antiretroviral therapy—A systematic review and meta-analysis
Introduction: Antiretroviral therapy-naïve pregnant women living with HIV are at an increased risk for adverse pregnancy outcomes. It remains controversial whether this risk persists with antiretroviral therapy. We conducted a systematic...
Exploring linkages between drought and HIV treatment adherence in Africa: A systematic review
Climate change is directly and indirectly linked to human health, including through access to treatment and care. Our systematic review presents a systems understanding of the nexus between drought and...
Vitamin D and calcium supplementation reverses tenofovir-caused bone mineral density loss in people taking ART or PrEP: A systematic review and meta-analysis
BACKGROUND: The decrease of bone mineral density (BMD) after the intake of Tenofovir disoproxil fumarate (TDF)-based drugs in people living with HIV/AIDS (PLWHA) and HIV-negative key populations under pre-exposure prophylaxis...
Prevalence and associated factors of treatment failure among children on ART in Ethiopia: A systematic review and meta-analysis
BACKGROUND: As the use of antiretroviral therapy (ART) increases, the issue of treatment failure is still a global challenge, particularly in a resource limited settings including Ethiopia. The results of...
