Category Archives: Treatment

Sexual and reproductive health of women living with HIV in Muslim-majority countries: A systematic mixed studies review

2020

BACKGROUND: The number of women living with the human immunodeficiency virus (WLHIV) in Muslim-majority countries has increased significantly in the last decade. These women are often marginalized and face insecure...

Antiretroviral therapy and detection of high-grade cervical intraepithelial neoplasia (CIN2+) at post-CIN management follow-up among women living with HIV: A systematic review and meta-analysis

2020

BACKGROUND: We evaluated the association of antiretroviral therapy (ART), CD4+ count and HIV plasma viral load (PVL) on high-grade cervical intraepithelial neoplasia (CIN2+) detection at follow-up after CIN management among...

The role of the clinical pharmacist in the management of people living with HIV in the modern antiretroviral era

2019

As the HIV epidemic has evolved, so too has the role of the clinical pharmacist (CP) in the management of people living with HIV (PLWH). The modern antiretroviral therapy (ART)...

Interventions to improve antiretroviral therapy adherence among adolescents and youth in low- and middle-income countries: A systematic review 2015-2019

2020

Adolescents and youth living with HIV have poorer antiretroviral treatment (ART) adherence and viral suppression outcomes than all other age groups. Effective interventions promoting adherence are urgently needed. We reviewed...

Using discrete choice experiments to develop and deliver patient-centered psychological interventions: A systematic review

2020

Developing and/or tailoring psychological interventions to align with patient preferences is a critical component of patient-centered care and has the potential to improve patient engagement and treatment outcomes. Discrete choice...

HBV infection in HIV-driven immune suppression

2019

Worldwide, approximately 10% of all human immunodeficiency virus (HIV)-infected people are also chronically coinfected with hepatitis B virus (HBV). HBV infection has a poor prognosis in HIV-positive people and has...

Adherence to antiretroviral therapy among HIV patients in India: A systematic review and meta-analysis

2020

We conducted a systematic review and meta-analysis to estimate the prevalence of adherence to antiretroviral therapy (ART) in India, the third largest HIV epidemic in the world. We identified peer...

Efficacy and safety of raltegravir-based dual therapy in AIDS patients: A meta-analysis of randomized controlled trials

2019

Background: The life expectancy for HIV-infected individuals has improved dramatically because of improvements in antiretroviral therapy (ART). Today, a simplified two-drug regimen enhances adherence and treatment satisfaction by reducing adverse...

HIV viral resuppression following an elevated viral load: A systematic review and meta-analysis

2019

INTRODUCTION: Guidelines for antiretroviral therapy recommend enhanced adherence counselling be provided to individuals with an initial elevated viral load before making a decision whether to switch antiretroviral regimen. We undertook...

Trend of HIV-1 drug resistance in China: A systematic review and meta-analysis of data accumulated over 17 years (2001-2017)

2020

Background: The emergence and spread of HIV-1 drug resistance may compromise HIV control globally. In response to HIV/AIDS epidemic, China launched national HIV/AIDS treatment program in 2003, and started to...

Treatment failure and associated factors among first line patients on highly active antiretroviral therapy in Ethiopia: A systematic review and meta-analysis

2019

Background: Antiretroviral therapy (ART) restores immune function and reduces human immunodeficiency virus (HIV) related adverse outcomes. The results of previous studies in Ethiopia were replete with inconsistent findings; nonexistence of...

Immunological and virological responses in older HIV-infected adults receiving antiretroviral therapy: An evidence-based meta-analysis

2020

Millions of people living with the human immunodeficiency virus (HIV) have received antiretroviral therapy (ART). Older adults make up a significant portion of these individuals, however, the immunological and virological...

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