Category Archives: Treatment

Integration of HIV testing services into family planning services: A systematic review

2019

BACKGROUND: Despite significant interest in integrating sexual and reproductive health (SRH) services into HIV services, less attention has been paid to linkages in the other direction. Where women and girls...

Guides concerning tenofovir exposure via breastfeeding: A comparison of drug dosages by developmental stage

2019

Tenofovir disoproxil fumarate (TDF) is a prodrug of tenofovir, and after being administrated orally, it converts to tenofovir in the blood. With the increasing use of TDF in women for...

Treatment adherence among mothers living with HIV in the US: A scoping review

2019

The purpose of this review was to understand research about treatment adherence among mothers in the US who are living with HIV. Treatment adherence included Antiretroviral Therapy and attending medical...

Second-line HIV treatment failure in sub-Saharan Africa: A systematic review and meta-analysis

2019

BACKGROUND: Increased second-line antiretroviral therapy (ART) failure rate narrows future options for HIV/AIDS treatment. It has critical implications in resource-limited settings; including sub-Saharan Africa (SSA) where the burden of HIV-infection...

Systematic review and meta-analysis of treatment interruptions in HIV-1 infected patients receiving antiretroviral therapy: Implications for future HIV cure trials

2019

BACKGROUND: Safety and tolerability of analytical treatment interruptions (ATIs) as a vital part of HIV-1 cure studies are discussed. We analyzed current evidence for occurrence of adverse events (AEs) during...

Behavioral economic insights to improve medication adherence in adults with chronic conditions: A scoping review

2019

Objective: The objective of this review is to map the evidence on the use of behavioral economic insights to improve medication adherence in adults with chronic conditions. Introduction: Medication non-adherence is a...

The protective effect of isoniazid preventive therapy on tuberculosis incidence among HIV positive patients receiving ART in Ethiopian settings: A meta-analysis

2019

BACKGROUND: Tuberculosis (TB) and HIV makeup a deadly synergy of infectious disease, and the combined effect is apparent in resource limited countries like Ethiopia. Previous studies have demonstrated inconsistent results...

Virologically suppressed HIV-infected patients on TDF-containing regimens significantly benefit from switching to TAF-containing regimens: A meta-analysis of randomized controlled trials

2019

BACKGROUND: To investigate whether TDF-containing regimens significantly benefited efficacy, safety, and tolerability in TAF-containing regimens in virologically suppressed HIV-infected patients. METHODS: PubMed, Embase, Web of Science, and the Cochrane T

Adherence to HIV treatment regimens: Systematic literature review and meta-analysis

2019

Background: Antiretroviral therapy (ART), when taken consistently, reduces morbidity and mortality associated with human immunodeficiency virus and viral transmission. Suboptimal treatment adherence is associated with regimen complexity and high tablet burden....

Which community-based HIV initiatives are effective in achieving UNAIDS 90-90-90 targets? A systematic review and meta-analysis of evidence (2007-2018)

2019

BACKGROUND: Reaching the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 targets to end the HIV epidemic relies on effective interventions that engage untested HIV+ individuals and retain them in...

Out-of-pocket costs associated with HIV in publicly funded high-income health care settings

2019

Key take-home messages The aging of the people living with HIV in care is leading to increased HIV care costs. There is considerable inter-jurisdictional heterogeneity in the cost-sharing policies for...

Associations between human leukocyte antigen polymorphisms and hypersensitivity to antiretroviral therapy in patients with human immunodeficiency virus: A meta-analysis

2019

Background Human leukocyte antigen (HLA) alleles are implicated in drug-induced hypersensitivity, including by nevirapine and abacavir. The purpose of this meta-analysis was to evaluate the relationship between HLA polymorphisms and...

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