Category Archives: Treatment

A systematic review of magnetic resonance imaging studies in perinatally HIV-infected individuals

2021

Over the past few years, neuroimaging studies have been performed in young adults with perinatally acquired HIV (PHIV) to study the impact of HIV infection on the central nervous system...

Cardiovascular risks associated with protease inhibitors for the treatment of HIV

2021

Introduction: Cumulative use of some first-generation protease inhibitors has been associated with higher rates of dyslipidemia and increased risk of cardiovascular disease. The protease inhibitors most commonly in use are...

Impact of nonadherence to antiretroviral therapy (ART) on population-level health outcomes

2021

Several studies analyze overall healthcare costs, pharmacy costs, and cost savings among people living with HIV relative to level of ART adherence. Generally, adherence to ART appears to predict levels...

Impact of universal coverage for antiretroviral therapy (ART) on health outcomes

2021

As of 2017, the annual cost of single-tablet antiretrovirals (ART) in Ontario was estimated to be CAD 15,552 according to the Ontario Drug Benefit Formulary. Universal, no-cost ART for all...

Cost-Effectiveness of antiretroviral therapy: A systematic review

2020

BACKGROUND: The mobilization of resources to prevent and treat human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) is unparalleled in the history of public health. The uptake of antiretroviral...

Effectiveness of naltrexone treatment for alcohol use disorders in HIV: A systematic review

2021

BACKGROUND: Because alcohol use disorders (AUDs) in patients living with HIV/AIDS are associated with a reduction in therapeutic outcomes and increases the risk of morbidity/mortality, finding an appropriate pharmacotherapy treatment...

Digital health for sexually transmitted infection and HIV services: A global scoping review

2021

PURPOSE OF REVIEW: The current study aimed to review how digital health has been used for sexually transmitted infection (STI)/HIV prevention, testing, and treatment. RECENT FINDINGS: A scoping review was...

What do HIV-positive drug users’ experiences tell us about their antiretroviral medication-taking? An international integrated literature review

2021

BACKGROUND AND AIMS: HIV-positive drug users’ poor adherence to antiretroviral regimens can pose a significant and negative impact on individual and global health. This review aims to identify knowledge gaps...

Strategies for retention of heterosexual men in HIV care in sub-Saharan Africa: A systematic review

2021

Expansion of Antiretroviral Therapy (ART) programs in sub-Saharan Africa (SSA) has increased the number of people accessing treatment. However, the number of males accessing and being retained along the human...

Effectiveness and safety of dolutegravir two-drug regimens in virologically suppressed people living with HIV: A systematic literature review and meta-analysis of real-world evidence

2021

Objectives: Dolutegravir (DTG) is widely recommended within three-drug regimens. However, similar efficacy and tolerability have also been achieved with DTG within two-drug regimens in clinical trials. This study evaluated the real-world...

The impact of antiretroviral therapy on neurocognitive outcomes among people living with HIV in low- and middle-income countries (LMICs): A systematic review

2021

Low and middle-income countries (LMICs) are the epicenter of the HIV epidemic. The scale-up of antiretroviral therapy (ART) has reduced mortality, but HIV-associated neurocognitive impairment (HANI) remains prevalent, which impacts...

Risk factors for loss to follow-up from antiretroviral therapy programmes in low-income and middle-income countries

2021

Introduction: Loss to follow-up (LTFU) rates from antiretroviral treatment (ART) programmes in low- and middle-income countries (LMIC) are high, leading to poor treatment outcomes and onward transmission of HIV. Knowledge of...

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