Category Archives: Treatment
Health technology-enabled interventions for adherence support and retention in care among US HIV-infected adolescents and young adults: An integrative review
The objective of this integrative review was to describe current US trends for health technology-enabled adherence interventions among behaviorally HIV-infected youth (ages 13-29 years), and present the feasibility and efficacy...
A historical review of HIV prevention and care initiatives in British Columbia, Canada: 1996-2015
INTRODUCTION: British Columbia has made significant progress in the treatment and prevention of HIV since 1996, when Highly Active Antiretroviral Therapy (HAART) became available. However, we currently lack a historical...
Evidence on the cost-effectiveness of lifelong antiretroviral therapy for prevention of mother-to-child transmission of HIV: Implications for resource-limited countries in sub-Saharan Africa
INTRODUCTION: The 2016 World Health Organization (WHO) consolidated guideline recommends lifelong antiretroviral therapy (ART) for all HIV-infected pregnant and breastfeeding women for preventing mother-to-child HIV transmission (PMTCT). Ambiguity remains about...
Where is the evidence? The use of routinely-collected patient data to retain adults on antiretroviral treatment in low and middle income countries-a state of the evidence review
Retention rates in antiretroviral treatment (ART) in low- and middle-income countries are suboptimal for meeting global “90-90-90” treatment targets. Interventions using routinely collected patient data to follow up with ART...
Effect of frequency of clinic visits and medication pick-up on antiretroviral treatment outcomes: A systematic literature review and meta-analysis
INTRODUCTION: Expanding and sustaining antiretroviral therapy (ART) coverage may require simplified HIV service delivery strategies that concomitantly reduce the burden of care on the health system and patients while ensuring...
Clinical and public health implications of acute and early HIV detection and treatment: A scoping review
INTRODUCTION: The unchanged global HIV incidence may be related to ignoring acute HIV infection (AHI). This scoping review examines diagnostic, clinical, and public health implications of identifying and treating persons...
Systematic review and meta-analysis of the adolescent HIV continuum of care in South Africa: the Cresting Wave
CONTEXT: South Africa has the most HIV infections of any country in the world, yet little is known about the adolescent continuum of care from HIV diagnosis through viral suppression....
HIV-free survival at 12-24 months in breastfed infants of HIV-infected women on antiretroviral treatment
OBJECTIVE: To provide estimates of HIV-free survival at 12-24 months in breastfed children by maternal ART (6 months or lifelong) to inform WHO HIV and Infant Feeding guidelines. METHODS: Eighteen...
Global prevalence of hypertension among people living with HIV: A systematic review and meta-analysis
The purpose of this study was to estimate, through meta-analysis, the global prevalence of hypertension among people living with HIV (PLWH). A total of 49 studies published during 2011-2016 with...
A review of the efficacy and safety of genvoya(R) (elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide) in the management of HIV-1 infection
INTRODUCTION: This review evaluates the efficacy and safety of Genvoya(R) (elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide [EVG/c/TAF/FTC]), a single-tablet regimen used for the management of HIV-1 infection. Phase II and...
Critical review: What dose of rifabutin is recommended with antiretroviral therapy?
Since the advent of combination antiretroviral therapy to successfully treat HIV infection, drug-drug interactions (DDIs) have become a significant problem as many antiretrovirals (ARVs) are metabolized in the liver. Antituberculous...
HIV-associated executive dysfunction in the era of modern antiretroviral therapy: A systematic review and meta-analysis
OBJECTIVE: While some reports suggest that HIV+ individuals continue to display executive function (EF) impairment in the era of cART, findings have been contradictory and appear to differ based on...
