Category Archives: Engagement and Care Cascade
Barriers and facilitators to maintaining a high level of polypharmacy adherence in people living with HIV: A scoping review
Objectives: With the prolongation of life span and increasing incidence of comorbidities, polypharmacy has become a challenge for people living with HIV/AIDS (PLWH). This review aimed to identify barriers and...
Does telehealth affect the adherence to ART among patients with HIV? A systematic review and meta-analysis
Background Several studies have shown different effects of telehealth interventions on adherence to Antiretroviral therapy (ART) among people living with HIV. This study conducted a meta-analysis of Randomized Controlled Trials...
Immediate treatment for recent hepatitis C infection in people with high-risk behaviors: A systematic review and meta-analysis
BACKGROUND AND AIMS: Direct-acting antivirals (DAAs) are almost exclusively approved for the treatment of chronic HCV. This poses a significant barrier to the treatment of recently acquired HCV because of...
Dysphagia and pill swallowing in HIV/AIDS in South Africa: Results of a scoping review
BACKGROUND: South Africa has the highest prevalence of human immunodeficiency virus (HIV) worldwide. Highly active antiretroviral therapy (HAART) is expected to improve the quality of life for these individuals but...
Health economic analyses of latent tuberculosis infection screening and preventive treatment among people living with HIV in lower tuberculosis incidence settings: A systematic review
Introduction: In lower tuberculosis (TB) incidence countries (<100 cases/100,000/year), screening and preventive treatment (PT) for latent TB infection (LTBI) among people living with HIV (PLWH) is often recommended, yet guidelines...
Influencing factors and adverse outcomes of virologic rebound states in anti-retroviral-treated individuals with HIV infection
Antiretroviral therapy (ART) aims to inhibit HIV replication, decrease CD4 T cell loss, and immune function recovery in order to reduce the morbidity and mortality associated with the infection. Treatment...
Nutritional status and its determinants among adolescents with HIV on anti-retroviral treatment in low- and middle-income countries: A systematic review and meta-analysis
Purpose This review aimed to determine what methods are used to assess nutritional status, the levels of nutritional status, determinants of undernutrition, and nutritional interventions employed for adolescents with HIV...
Contribution of low CD4 cell counts and high HIV viral load to the efficacy of preferred first-line antiretroviral regimens for treating HIV infection: A systematic review and meta-analysis
We assessed whether low CD4 count and high viral load (VL) affect the response to currently preferred ART. We performed a systematic review of randomized, controlled clinical trials that analyzed...
Intergenerational spillover effects of antiretroviral therapy in sub-Saharan Africa: A scoping review and future directions for research
BACKGROUND: Antiretroviral therapy (ART) may influence individuals who do not receive the intervention but who are connected in some way to the person who does. Relatively little is known, however,...
“What’s sex and gender got to do with it?” A scoping review of sex and gender-based analysis in pharmacoepidemiologic studies of medication adherence
BACKGROUND: Medication taking is a complex multidimensional behaviour that may be impeded by a range of biological and psychosocial factors, including sex and gender. We aimed to synthesize how sex...
Disparities in healthcare access and utilization among people living with HIV in China: A scoping review and meta-analysis
Background Healthcare disparities hinder the goal of ending the HIV pandemic by 2030. This review aimed to understand the status of healthcare disparities among people living with HIV (PLWH) in...
The recent natural history of human papillomavirus cervical infection in women living with HIV: A scoping review of meta-analyses and systematic reviews and the construction of a hypothetical model
Background: Women with HIV are more often infected with human papillomavirus (HPV) and are more prone to develop precancerous cervical lesions (squamous intraepithelial lesions, SIL) and invasive cervical cancer (ICC) than...
