Category Archives: Engagement and Care Cascade
Climate change and extreme weather events and linkages with HIV outcomes: Recent advances and ways forward
PURPOSE OF REVIEW: Discuss the recent evidence on climate change and related extreme weather events (EWE) and linkages with HIV prevention and care outcomes. RECENT FINDINGS: We identified 22 studies...
Retention in care after transition to adult care for adolescents and young adults with HIV: A systematic review and meta-analysis
Objective: To evaluate the retention rates of adolescents and young adults (aged 10-25 years) living with HIV during the transition to adult HIV care. Methods: The study involved 15 cohort studies conducted...
Incidence of adverse drug reactions among HIV patients on antiretroviral drugs in Ethiopia: A systematic review and meta-analysis
Introduction: In recent decades, AIDS–related illnesses have declined due to the widespread use of highly active antiretroviral therapy (HAART). Despite the numerous benefits that HAART provides, it causes significant challenges for...
Efficacy of long-acting cabotegravir plus rilpivirine in viraemic people living with HIV: A systematic review and meta-analysis
BACKGROUND: Long-acting cabotegravir/rilpivirine (LA-CAB/RPV) is currently approved as a switch strategy in people living with HIV virally suppressed on oral antiretroviral therapy. Although small reports on specific, difficult-to-treat populations demonstrated...
Understanding HIV-exposed uninfected children: A narrative review
The widespread implementation of antiretroviral therapy has significantly reduced HIV-related mortality and mother-to-child transmission. Despite being HIV-uninfected, HIV-exposed children (HEU) seem to face heightened risks of immune dysfunction, cardiometabolic diseases,...
Causes of hospitalisation among people living with HIV worldwide, 2014-23: A systematic review and meta-analysis
Background: Despite improved access to antiretroviral therapy (ART), HIV-related morbidity and mortality remain high. A previous review (2007-14) found that AIDS-related illnesses were the leading causes of hospitalisations. We aimed to...
Depressive symptoms and its determinants among people living with HIV in Africa: Systematic review and meta-analysis
Background: In Africa, depressive symptoms are prevalent among people living with HIV (PLHIV), significantly impacting their adherence and overall quality of life. The combined burden of HIV and depressive symptoms worsens...
Prevalence of late HIV diagnosis and its impact on mortality: A comprehensive systematic review and meta-analysis
Objectives: The late diagnosis of HIV infection plays a crucial role in accelerating the disease progression and increasing the risk of death in the HIV population. However, there remains no consensus...
The impact of place of residence on antiretroviral therapy adherence: A systematic review and meta-analysis
Objective: There is evidence of geographical variation in HIV coverage and antiretroviral therapy (ART) adherence, and studies have investigated how the place of residence of people living with HIV (PLWH) influences...
Prevalence and predictors of virological failure among the people living with HIV on antiretroviral treatment in East Africa: Evidence from a systematic review with meta-analysis and meta-regression of published studies from 2016 to 2023
Background: Virological failure (VF) significantly threatens the efficacy of antiretroviral therapy (ART) programs in East Africa. This systematic review and meta-analysis assess the prevalence and predictors of VF among individuals living...
Evidence on digital HIV self-testing from accuracy to impact: Updated systematic review
BACKGROUND: HIV self-testing has gained momentum following the approval of self-testing methods and novel technological advancements. Digital HIV self-testing involves completing an oral or blood-based HIV self-test with support from...
