Category Archives: Engagement and Care Cascade

The manifesto of pharmacoenosis: Merging HIV pharmacology into pathocoenosis and syndemics in developing countries

2021

Pathocoenosis and syndemics theories have emerged in the last decades meeting the frequent need of better understanding interconnections and reciprocal influences that coexistent communicable and non-communicable diseases play in a...

Nutrition in HIV-infected infants and children: Current knowledge, existing challenges, and new dietary management opportunities

2021

HIV infection and undernutrition remain significant public health concerns for infants and children. In infants and children under these conditions, undernutrition is one of the leading causes of death. Proper...

Effect of pharmacist care on clinical outcomes among people living with HIV/AIDS: A systematic review and meta-analysis

2021

BACKGROUND: Pharmacists play a significant role in the multidisciplinary care of people living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (PLWHA). However, there is less evidence to clarify the...

Effects of probiotics on diarrhea and CD4 cell count in people living with HIV: A systematic review and meta-analysis

2021

Gastrointestinal probiotics play an important role in maintaining intestinal bacteria homeostasis. They might benefit people with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), which remains a global health challenge. However, there...

Eliminating HIV reservoirs for a cure: The issue is in the tissue

2021

PURPOSE OF REVIEW: Advances in antiretroviral therapy have saved numerous lives, converting a diagnosis with human immunodeficiency virus 1 (HIV-1) from a death sentence into the possibility for a (nearly)...

Assessing proviral competence: Current approaches to evaluate HIV-1 persistence

2021

PURPOSE OF REVIEW: Despite decades of suppressive antiretroviral therapy (ART), HIV-1 reservoirs persist and fuel viral rebound if therapy is interrupted. The persistence of viral reservoirs in infected individuals is...

Improving retention in antenatal and postnatal care: A systematic review of evidence to inform strategies for adolescents and young women living with HIV

2021

INTRODUCTION: Young pregnant and postpartum women living with HIV (WLHIV) are at high risk of poor outcomes in prevention of mother-to-child transmission services. The aim of this systematic review was...

Sex differences in HIV testing among older adults in sub-Saharan Africa: A systematic review

2021

BACKGROUND: Despite being sexually active and engaging in risky sexual behaviours similar to young adults, older adults (50 years or older) are less likely to receive HIV testing, and disaggregated...

A narrative review of the renin-angiotensin-aldosterone system in the placenta and placental bed of HIV infected women of African ancestry with preeclampsia

2021

PURPOSE OF REVIEW: Both HIV infection and preeclampsia (PE), a pregnancy-specific disorder of hypertension and multi-system organ involvement, have high prevalence rates especially in low-to-middle-income countries. The immunoexpression of specific...

Prescribing intranasal steroids in HIV-positive patients: Systematic review of the literature

2021

BACKGROUND: There are significant drug-drug interactions between human immunodeficiency virus antiretroviral therapy and intranasal steroids, leading to high serum concentrations of iatrogenic steroids and subsequently Cushing’s syndrome. METHOD: All articles...

Considerations for successful therapeutic immunization in HIV cure

2021

PURPOSE OF REVIEW: In this special issue on human immunodeficiency (HIV) cure, we review the role of therapeutic immunization in strategies aimed to eliminate HIV-infected cells and/or mediate sustained control...

Immunological effector mechanisms in HIV-1 elite controllers

2021

PURPOSE OF REVIEW: HIV-1 elite controllers encompass small populations of people infected with HIV-1 who can spontaneously control plasma viral loads below the limit of detection, in the absence of...

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