Category Archives: Engagement and Care Cascade
Rapid initiation of antiretroviral therapy for people living with HIV
BACKGROUND: Despite antiretroviral therapy (ART) being widely available, HIV continues to cause substantial illness and premature death in low-and-middle-income countries. High rates of loss to follow-up after HIV diagnosis can...
Comparative efficacy and safety and dolutegravir and lamivudine in treatment naive HIV patients
Objective: Compare the efficacy and safety of the 2-drug antiretroviral therapy regimen dolutegravir + lamivudine (DTG + 3TC) with traditional 3-drug regimens in treatment-naive patients with HIV-1. Design: Data from double-blind, randomized...
Tenofovir-associated kidney disease in Africans: A systematic review
BACKGROUND: Data on chronic kidney disease development in HIV infection is important towards building a comprehensive knowledge of HIV, ageing and polypharmacy in Africa. Several previous studies on tenofovir-associated kidney...
Recent interventions to improve retention in HIV care and adherence to antiretroviral treatment among adolescents and youth: A systematic review
Adolescents represent a growing proportion of people living with HIV worldwide and the highest risk population group for treatment attrition and AIDS-related mortality. There is an urgent need to design,...
Do quality improvement initiatives improve outcomes for patients in antiretroviral programs in low- and middle-income countries? A systematic review
Background: There have been a range of quality improvement (QI) and quality assurance initiatives in low- and middle-income countries to improve antiretroviral therapy (ART) treatment outcomes for people living with HIV....
Self-disclosure of HIV status among youth living with HIV: A global systematic review
Self-disclosure of HIV serostatus by youth has been considered an essential component of HIV prevention and medication adherence efforts. Therefore, a comprehensive investigation of disclosure goals, processes, and outcomes is...
Antiretroviral concentration in hair as a measure for antiretroviral medication adherence: A systematic review of global literature
This review aims to validate hair antiretroviral concentration (HAC) as a measure for antiretroviral medication adherence. This review included 31 studies that analyzed a total of 11 ARV drugs in...
Long-term effects of psychological interventions to improve adherence to antiretroviral treatment in HIV-infected persons: A systematic review and meta-analysis
We examined the efficacy of psychological adherence-enhancing interventions (AEIs) compared with usual care in HIV-infected adults under antiretroviral treatment (ART) by focusing on adherence and clinical HIV markers as outcomes...
Challenges and support for quality of life of youths living with HIV/AIDS in schools and larger community in East Africa: A systematic review
BACKGROUND: Youths living with HIV/AIDS (YLWHA) experience innumerable challenges within schools and the larger community. Nonetheless, these environments are potential sources of support for such youths. This review provides a...
