Category Archives: Engagement and Care Cascade
Virologic Failure and Emergent Integrase Strand Transfer Inhibitor Drug Resistance With Long-Acting Cabotegravir for HIV Treatment: A Meta-analysis
BACKGROUND: The long-acting injectable regimen of cabotegravir plus rilpivirine (CAB/RPV) emerged as an alternative to oral standard-of-care integrase strand transfer inhibitor (INSTI)-based regimens for individuals with adherence challenges or preference...
Single-session interventions to enhance HIV outcomes among adolescents and young adults: A systematic scoping review and implications for integrating HIV and mental health services
Significant progress has been made in HIV prevention and treatment for adolescents and young adults (AYA), but integrating mental healthcare remains essential to address risks and improve treatment engagement. Single-session...
Probability of vertical HIV transmission: A systematic review and meta-regression
Background Eliminating HIV vertical transmission is a global priority and monitored by estimating paediatric HIV infections with the UNAIDS-supported Spectrum AIDS Impact Module (Spectrum-AIM). Recent innovations in antiretroviral therapy (ART)...
The impact of antiretroviral therapy (ART) on HPV persistence and cervical cancer progression among women with HPV/HIV co-infection: A systematic review
Cervical cancer remains the leading cause of cancer-related morbidity and mortality among women globally, particularly in low- and middle-income countries. Women living with HIV are at risk of persistent high-risk...
Mobile health intervention tools promoting HIV pre-exposure prophylaxis among adolescent girls and young women in sub-Saharan Africa: Scoping review
BACKGROUND: In 2022, 3100 adolescent girls and young women in sub-Saharan Africa experienced new HIV infections each week. HIV pre-exposure prophylaxis (PrEP) is effective at preventing HIV but has limited...
Cost-effectiveness analyses of adolescent- and young-adult-focused HIV interventions incorporating HIV transmission: A scoping review of modeling methods and proposed guidance
BACKGROUND: Adolescents and young adults (AYA) are disproportionately affected by human immunodeficiency virus (HIV) globally, with high-burden population subgroups differing across regions. Cost-effectiveness modeling analyses of AYA-focused HIV interventions have...
Implementation of trauma-informed care into clinical HIV prevention and care settings: A decade of limited progress
PURPOSE OF THE REVIEW: Trauma is common among people living with or at risk for HIV and associated with increased HIV risk and worse HIV care outcomes. Trauma-informed care (TIC)...
Guidelines for the transfer of people living with HIV attending primary healthcare facilities in South Africa: A scoping review
People living with HIV may move between health facilities: this is called ‘transfer’, and includes up- and down-referral based on clinical condition and lateral transfer (e.g. between primary healthcare [PHC]...
Patient-reported outcomes in clinical trials assessing the effectiveness of cabotegravir + rilpivirine long-acting injections as antiretroviral therapy: A systematic review
Introduction: Human immunodeficiency virus-1 (HIV-1) continues to have ahigh global burden, with approximately 39.9 million people currently livingwith the virus. Despite the clinical success of antiretroviral therapy (ART),adherence remains a...
