Category Archives: Prevention, Engagement and Care Cascade
Efficacy of long-acting injectable cabotegravir and rilpivirine compared with daily oral antiretroviral therapy in patients with HIV: A systematic review
Long-acting antiretroviral therapy (ART) has emerged as an innovative strategy to address limitations associated with daily oral regimens in people living with human immunodeficiency virus type 1 (HIV-1), including adherence...
Effectiveness and safety of darunavir and lopinavir for treating children and adolescents living with HIV: A systematic review
Introduction Darunavir and lopinavir solid formulations are recommended protease inhibitors for treating HIV. An evidence review of their effectiveness/efficacy and safety in young populations was needed to inform the 2025...
Global Perspectives on Pre-Exposure Prophylaxis: A Systematic Review and Meta-Analysis of Health Care Providers’ Awareness, Willingness, and Barriers
This systematic review and meta-analysis aimed to assess health care providers’ awareness, willingness, and key barriers in implementing HIV pre-exposure prophylaxis (PrEP). The review followed the Preferred Reporting Items for...
Systematic literature review and meta-analysis of INSTI-based antiretroviral therapy single- versus multiple-tablet regimens for the treatment of HIV
Introduction Antiretroviral single-tablet regimens (STRs) have several advantages over multiple-tablet regimens (MTRs), including increased adherence and improved treatment satisfaction for people with HIV (PWH). This analysis has systematically reviewed and...
Understanding antiretroviral therapy adherence in children with HIV: A review of barriers and strategies
INTRODUCTION: Despite advancements in antiretroviral therapy (ART) availability, maintaining optimal adherence remains difficult, especially in low- and middle-income countries (LMICs). This literature review synthesized evidence on barriers and interventions influencing...
A scoping review of the methods, content, and populations of rural LGBTQ health research since the new millennium
INTRODUCTION: This scoping review mapped the population characteristics, methodologies, content, and publishing trends of primary research focused on rural LGBTQ individuals since the year 2000. METHODS: We conducted a search...
Harm reduction progams and interventions for equity-deserving populations who use crack-cocaine. A scoping review
BACKGROUND: Crack-cocaine use is associated with severe physical and mental health consequences, including cardiac, pulmonary and psychiatric conditions. It also heightens the risk of overdose and transmission of infectious diseases...
Role of pharmacists in HIV prophylaxis: A scoping review of pharmacists’ services, interventions and outcomes
INTRODUCTION: HIV remains a major global public health challenge, with nearly 1.3 million new HIV acquisitions annually. Despite the effectiveness of pre-exposure (PrEP) and post-exposure prophylaxis (PEP), barriers to access,...
Vulnerability and non-adherence to treatment in cisgender women living with HIV/AIDS: A scoping review (2000–2024)
Background Cisgender women are disproportionately affected by HIV/AIDS due to structural gender inequalities and intersecting social determinants, which generate vulnerability contexts that act as barriers to treatment adherence. Methods A...
Knowledge of reproductive-age women about mother-to-child transmission of HIV and associated factors: A systematic review and meta-analysis
INTRODUCTION: Despite significant efforts to manage and prevent HIV, knowledge gaps persist regarding mother-to-child transmission of HIV among women of reproductive age. Previous studies, limited in scope and producing inconsistent...
Virologic suppression among HIV-positive pregnant and lactating women receiving antiretroviral therapy in Africa: A systematic review and meta-analysis
Background The elimination of mother-to-child transmission of human immunodeficiency virus (HIV) is a key global public health priority. In Africa, virologic failure among people living with HIV continues to pose a...
Peer network approaches for improving HIV testing, prevention and care utilisation among men in sub-Saharan Africa: A scoping review
INTRODUCTION: Limited male engagement in HIV prevention and care is a global challenge more pronounced in sub-Saharan Africa (SSA) contributing to ongoing transmission. However, peer network interventions show promise in...
