Category Archives: Prevention, Engagement and Care Cascade
Antiretroviral therapy for pregnant women living with HIV or hepatitis B: A systematic review and meta-analysis
OBJECTIVE: To assess the impact of various antiretroviral/antiviral regimens in pregnant women living with HIV or hepatitis B virus (HBV). DESIGN: We performed random effects meta-analysis for HIV-related outcomes and...
Prevalence and factors associated with depression in people living with HIV in sub-Saharan Africa: A systematic review and meta-analysis
Depression, one of the most common psychiatric disorders, is two- to three-times more prevalent in people living with HIV (PLHIV) than in the general population in many settings as shown...
Association between male circumcision and women’s biomedical health outcomes: A systematic review
BACKGROUND: Male circumcision reduces men’s risk of acquiring HIV and some sexually transmitted infections from heterosexual exposure, and is essential for HIV prevention in sub-Saharan Africa. Studies have also investigated...
Vitamin A supplements for reducing mother-to-child HIV transmission
BACKGROUND: Strategies to reduce the risk of mother-to-child transmission of the human immunodeficiency virus (HIV) include lifelong antiretroviral therapy (ART) for HIV-positive women, exclusive breastfeeding from birth for six weeks...
Association between medication regimen complexity and pharmacotherapy adherence: A systematic review
PURPOSE: The purpose of this study was to systematically review evidence regarding the association between regimen complexity and adherence. METHODS: Articles were searched in MEDLINE, LILACS, Cochrane, CINAHL, PsycINFO and...
Zidovudine/lamivudine vs. abacavir/lamivudine vs. tenofovir/emtricitabine in fixed-dose combinations as initial treatment for HIV patients: A systematic review and network meta-analysis
INTRODUCTION: Initial treatment of the HIV is based on the use of three drugs, two of which are nucleoside analog reverse-transcriptase inhibitors. There are three combinations of these drugs which...
Opportunities and gaps in primary care preventative health services for transgender patients: A systemic review
Purpose: Transgender people face barriers to accessing healthcare, resulting in population-level disparities in health outcomes. Little research is available to better understand the receipt of primary healthcare among transgender patients...
Health technology-enabled interventions for adherence support and retention in care among US HIV-infected adolescents and young adults: An integrative review
The objective of this integrative review was to describe current US trends for health technology-enabled adherence interventions among behaviorally HIV-infected youth (ages 13-29 years), and present the feasibility and efficacy...
Pharmacogenetic considerations for HIV treatment in different ethnicities: An update
INTRODUCTION: Variations in the human genome sequence sometimes play an important role in pharmacokinetics and/or pharmacodynamics. Previous studies have demonstrated a high degree of variation both between and within different...
Shifting tasks from pharmacy to non-pharmacy personnel for providing antiretroviral therapy to people living with HIV: A systematic review and meta-analysis
OBJECTIVES: Lay people or non-pharmacy health workers with training could dispense antiretroviral therapy (ART) in resource-constrained countries, freeing up time for pharmacists to focus on more technical tasks. We assessed...
Does pre-exposure prophylaxis (PrEP) for HIV prevention in men who have sex with men (MSM) change risk behavior? A systematic review
BACKGROUND: Pre-exposure prophylaxis (PrEP) for HIV has been available since 2012. Even so, PrEP has not been widely accepted among healthcare providers and MSM some of whom are convinced that...
Implementation effectiveness of revised (post-2010) World Health Organization guidelines on prevention of mother-to-child transmission of HIV using routinely collected data in sub-Saharan Africa: A systematic literature review
BACKGROUND: To synthesize and evaluate the impact of implementing post-2010 World Health Organization (WHO) prevention of mother-to-child transmission (PMTCT) guidelines on attainment of PMTCT targets. METHODS: Retrospective and prospective cohort...
