Category Archives: Prevention, Engagement and Care Cascade
Dolutegravir plus two nucleoside reverse transcriptase inhibitors versus efavirenz plus two nucleoside reverse transcriptase inhibitors as initial antiretroviral therapy for people with HIV: A systematic review
BACKGROUND: Dolutegravir (DTG) is a once-daily unboosted second-generation integrase-inhibitor that along with two nucleoside reverse transcriptase inhibitors is one of several regimens recommended by the United States, United Kingdom and...
Life expectancy of HIV-positive people after starting combination antiretroviral therapy: A meta-analysis
OBJECTIVES: Life expectancy is an important indicator informing decision making in policies relating to HIV-infected people. Studies estimating life expectancy after starting combination antiretroviral therapy (cART) have noted differences between...
A systematic review of interventions to improve postpartum retention of women in PMTCT and ART care
INTRODUCTION: The World Health Organization recommends lifelong antiretroviral therapy (ART) for all pregnant and breastfeeding women living with HIV. Effective transitioning from maternal and child health to ART services, and...
Internet-based partner selection and risk for unprotected anal intercourse in sexual encounters among men who have sex with men: A meta-analysis of observational studies
INTRODUCTION: Men who have sex with men (MSM) who identify sex partners over the internet are more likely than other MSM to report having unprotected anal intercourse (UAI). It is...
Prevalence of alcohol use, sexual risk behavior, and HIV among Russians in high-risk settings: A systematic review and meta-analysis
PURPOSE: The purpose of this study was to examine the (a) prevalence of and (b) association between alcohol, risky sex, and HIV among Russians at risk for primary or secondary...
Interventions to reduce loss to follow-up during all stages of the HIV care continuum in sub-Saharan Africa: A systematic review
The continuum of care for successful HIV treatment includes HIV testing, linkage, engagement in care, and retention on antiretroviral therapy (ART). Loss to follow-up (LTFU) is a significant disruption to...
Comparing psychosocial correlates of condomless anal sex in HIV-diagnosed and HIV-nondiagnosed men who have sex with men: A series of meta-analyses of studies from 1993–2013
PURPOSE: Men who have sex with men (MSM) continue to be overrepresented in rates of incidence and prevalence of human immunodeficiency virus (HIV). Both HIV-diagnosed (HIV-D) and HIV-nondiagnosed (HIV-N) MSM...
A meta-analysis assessing all-cause mortality in HIV-exposed uninfected compared to HIV-unexposed uninfected infants and children
OBJECTIVE: Conduct a meta-analysis examining differential all-cause mortality rates between HIV-exposed uninfected infants and children as compared to their HIV-unexposed uninfected counterparts. DESIGN: Meta-analysis summarizing the difference in mortality between...
Interventions to strengthen the HIV prevention cascade: A systematic review of reviews
BACKGROUND: Much progress has been made in interventions to prevent HIV infection. However, development of evidence-informed prevention programmes that translate the efficacy of these strategies into population effect remain a...
Disparities in the magnitude of human immunodeficiency virus-related opportunistic infections between high and low/middle-income countries: Is highly active antiretroviral therapy changing the trend?
Opportunistic infections (OIs) cause significant morbidity/mortality in human immunodeficiency virus (HIV)-infected individuals globally. Disparities between high-income countries (HICs) and low/middle-income countries (LMICs) in the magnitude of HIV-related OIs in pre-highly...
The use of social networking applications of smartphone and associated sexual risks in lesbian, gay, bisexual, and transgender populations: A systematic review
The use of social networking applications (apps) on smartphones has the potential to impact sexual health and behaviour. This was the first systematic review to critically appraise and summarize the...
Surveillance of HIV transmitted drug resistance in Latin America and the Caribbean: A systematic review and meta-analysis
BACKGROUND: HIV transmitted drug resistance (TDR) remains at moderate level in Latin America and the Caribbean (LAC). However, different epidemiologic scenarios could influence national and sub-regional TDR levels and trends....
