Category Archives: Prevention, Engagement and Care Cascade
Effectiveness of Pre-exposure Prophylaxis (PrEP) in the Prevention of Human Immunodeficiency Virus (HIV): A Systematic Review of Randomized Controlled Trials With Narrative Synthesis
Human immunodeficiency virus (HIV) prevention has advanced substantially, yet ending new transmissions by 2030 remains uncertain. Pre-exposure prophylaxis (PrEP) has high biological efficacy, but real-world effectiveness varies due to adherence,...
Alternative Administration of Antiretroviral Therapy in People with HIV Unable to Swallow: A Scoping Review
PURPOSE: To review published evidence on alternative administration methods for antiretroviral therapy in patients unable to swallow tablets. METHODS: We conducted a scoping review using PubMed, Web of Science, and...
Effect of donor exclusion criteria on blood safety and volume of donations: a systematic review of modelling studies
OBJECTIVE: To assess the effect of easing bans and deferral policies on blood donation from men who have sex with men on blood safety and volume from modelling studies. METHODS:...
Effects of transition from paediatric to adult HIV care on virological outcomes in sub-Saharan Africa: A systematic review and meta-analysis
BACKGROUND: HIV remains a major global burden, with 2.4 million children and adolescents affected, 84% living in sub-Saharan Africa. As adolescents age, transitioning from paediatric to adult HIV care represents...
Global coverage of interventions for reduction of injecting drug use-related harm, HIV, viral hepatitis and tuberculosis in prisons and other carceral settings: A systematic review
BACKGROUND: People who are incarcerated experience disproportionately high rates of injecting drug use and infectious disease, including HIV, viral hepatitis and tuberculosis. However, comprehensive global data regarding the availability of...
The vaginal microbiome of pregnant people living with HIV on antiretroviral therapy in the Democratic Republic of Congo: a pilot study and global meta-analysis
Recent studies reveal that a suboptimal vaginal microbiome (VMB), including the enrichment of anaerobic bacteria associated with multiple female genital disorders, is linked to adverse pregnancy and birth outcomes in...
Rapid diagnostic tests, laboratory-based immunoassay and nucleic acid testing strategies for long-acting injectable pre-exposure prophylaxis: A systematic review and meta-analysis
BACKGROUND: Long-acting injectable pre-exposure prophylaxis (LAI-PrEP) is a highly effective biomedical intervention for the prevention of HIV acquisition. There is a strong interest among communities and policymakers for LAI-PrEP scale-up,...
Effectiveness of mobile health (mHealth) interventions on ART adherence among people living with HIV in low- and middle-income countries: a systematic review and meta-analysis
Antiretroviral therapy (ART) is essential for HIV treatment, yet maintaining high adherence remains challenging in resource-limited settings. Mobile health (mHealth) interventions offer a scalable approach to support adherence. This meta-analysis...
Barriers and Facilitators Influencing PrEP Uptake Among Men Who Have Sex with Men and Transgender Women in the United States: A Systematic Review
In the United States, men who have sex with men (MSM) and transgender women (TGW) have high HIV pre-exposure prophylaxis (PrEP) awareness, yet uptake rates remain extremely low. This signifies...
Incidence and predictors of loss to follow-up among adults on antiretroviral therapy in Ethiopia: a systematic review and meta-analysis of cohort studies
BACKGROUND: Loss to follow-up (LTFU) from antiretroviral therapy (ART) remains a major public health concern worldwide, including in Ethiopia. However, nationally representative pooled cohort data on LTFU among adults receiving...
Surveillance of HIV-1 drug resistance in Tanzania across the pre- and post-dolutegravir eras: A systematic review and meta-analysis
This systematic review and meta-analysis assessed the prevalence, mutation patterns, and factors associated with HIV drug resistance (HIVDR) in Tanzania. We searched PubMed/MEDLINE and Embase from January 1, 2006, to...
