Category Archives: Prevention, Engagement and Care Cascade
Effectiveness and safety of rilpivirine, a non-nucleoside reverse transcriptase inhibitor, in treatment-naive adults infected with HIV-1: A meta-analysis
Objective: The aim of this study was to determine the effectiveness and safety of rilpivirine in treatment-naive adults infected with HIV-1. Methods: We ran duplicate searches of multiple databases and...
Disclosure of HIV serostatus among pregnant and postpartum women in sub-Saharan Africa: A systematic review
Disclosure of one’s HIV status can help to improve uptake and retention in prevention of mother-to-child transmission of HIV services; yet, it remains a challenge for many women. This systematic...
Circumcision status and risk of HIV acquisition during heterosexual intercourse for both males and females: A meta-analysis
In this study, we evaluated if male circumcision was associated with lower HIV acquisition for HIV (-) males and HIV (-) females during normal sexual behavior. We performed a systematic...
Predictors and correlates of adherence to combination antiretroviral therapy (ART) for chronic HIV infection: A meta-analysis
BACKGROUND: Adherence to combination antiretroviral therapy (ART) is a key predictor of the success of human immunodeficiency virus (HIV) treatment, and is potentially amenable to intervention. Insight into predictors or...
HIV, antiretroviral therapy, and hypertensive disorders in pregnancy: A systematic review and meta-analysis
BACKGROUND: There are data to suggest that infection with HIV or use of highly active antiretroviral therapy increases the risk of hypertensive disorders in pregnancy. This systematic review and meta-analysis...
Retention in care prior to antiretroviral treatment eligibility in sub-Saharan Africa: A systematic review of the literature
OBJECTIVE: We aimed at summarising rates and factors associated with retention in HIV care prior to antiretroviral treatment (ART) eligibility in sub-Saharan Africa. DESIGN: We conducted a systematic literature review...
Systematic review and meta-analysis of community and facility-based HIV testing to address linkage to care gaps in sub-Saharan Africa
HIV testing and counselling is the first crucial step for linkage to HIV treatment and prevention. However, despite high HIV burden in sub-Saharan Africa, testing coverage is low, particularly among...
Condom effectiveness in reducing heterosexual HIV transmission: A systematic review and meta-analysis of studies on HIV serodiscordant couples
OBJECTIVE: This systematic review and meta-analysis aimed to reassess the effectiveness of condoms in reducing heterosexual transmission of HIV. METHODS: Medline, Scopus, and the ISI Web of Science databases were...
Safety and efficacy of lopinavir/ritonavir during pregnancy: A systematic review
The co-formulated, ritonavir-boosted protease inhibitor lopinavir is a frequently used component of HAART for treatment of HIV-infected women during pregnancy and prevention of mother-to-child transmission. We performed a systematic review...
A meta-analysis investigating incidence and features of stroke in HIV-infected patients in the highly active antiretroviral therapy era
OBJECTIVE: Recent studies have suggested a close biological and clinical association between HIV infection and risk of myocardial infarction, whereas contrasting data have been reported about incidence of stroke and...
