Category Archives: Prevention, Engagement and Care Cascade
Structured treatment interruptions (STI) in chronic suppressed HIV infection in adults
BACKGROUND: Although antiretroviral treatment (ART) has led to a decline in morbidity and mortality of HIV-infected patients in developed countries, it has also presented challenges. These challenges include increases in...
Complementary and alternative therapy (CAT) use and highly active antiretroviral therapy (HAART): Current evidence in the literature, 2000–2009
Aim and objective. To determine current evidence about the use of complementary and alternative medicine in the context of highly active antiretroviral therapy. The following objectives included identifying the risks...
Secrets and safety in the age of AIDS: Does HIV disclosure lead to safer sex?
To fuel the HIV/AIDS epidemic, HIV-seropositive individuals must interact unsafely with HIV-seronegative individuals. Research indicates that up to one third of individuals diagnosed with HIV continue to have unprotected sex,...
Systematic review of clinical trials evaluating low doses of stavudine as part of antiretroviral treatment
Stavudine is a nucleoside analogue used for the treatment of HIV-1 infection, as part of highly active antiretroviral treatment. In developing countries, stavudine is used widely, owing to low cost...
Nevirapine once daily: Pharmacology, metabolic profile and efficacy data of the new extended-release formulation
Introduction: Nevirapine (NVP), a non-nucleoside reverse transcriptase inhibitor, has been an important component of HIV infection treatment for many years. Currently, twice-a-day dosing is required for the successful application of...
Clinical trials of interactive computerized patient education: Implications for family practice
A systematic review of randomized clinical trials was conducted to evaluate the acceptability and usefulness of computerized patient education interventions. The Columbia Registry, MEDLINE, Health, BIOSIS, and CINAHL bibliographic databases...
Etravirine (TMC-125): The evidence for its place in the treatment of HIV-1 infection
Introduction: Etravirine is a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) specifically designed to suppress the replication of viruses resistant to the three currently approved NNRTIs efavirenz, nevirapine, and delavirdine. Aims:...
Safety of efavirenz in first-trimester of pregnancy: A systematic review and meta-analysis of outcomes from observational cohorts
Introduction: Data on efavirenz safety in first trimester pregnancy are conflicting. We conducted a systematic review and meta-analysis of the available evidence from observational cohorts., Methods: We ran duplicate searches...
HIV and HCV prevalence among entrants to methadone maintenance treatment clinics in China: A systematic review and meta-analysis
Background: Methadone maintenance treatment (MMT) was implemented in China since 2004. It was initiated in 8 pilot clinics and subsequently expanded to 738 clinics by the end of 2011. Numerous...
Efficacy and tolerability of initial antiretroviral therapy: A systematic review
OBJECTIVES: Successful antiretroviral therapy (ART) is largely attributed to the type of third drug. Guidelines recommend regimens without systematic review of all factors that might affect treatment success, such as...
