Category Archives: Prevention, Engagement and Care Cascade
Identifying effective strategies for improving engagement in HIV prevention and care among transgender persons in the United States: A systematic review
This systematic review synthesized published literature (2000–2023) to identify HIV interventions specifically designed for transgender persons in the United States (PROSPERO registration number: CRD42021256460). The review also summarized strategies for...
Analysis of drug-drug interactions in patients with HIV and metabolic syndrome
BACKGROUND: People with HIV (PWH) are living longer directly related to benefits of highly effective antiretroviral therapy (ART). However, concurrent with improved longevity is the growing prevalence of metabolic comorbidities...
Delving deeper into the mechanisms fundamental to HIV-associated immunopathology using single-cell sequencing techniques: A scoping review of current literature
Human immunodeficiency virus (HIV) infection has evolved into an established global pandemic over the past four decades; however, despite massive research investment globally, the precise underlying mechanisms which are fundamental...
Revisiting the prevalence of unhealthy alcohol use among ethnic minority immigrant gay, bisexual men, and other men who have sex with men in North America: A systematic review and meta-analysis
Unhealthy alcohol use is a significant public health concern among ethnic minority immigrant gay, bisexual men, and other men who have sex with men (GBMSM) in North America. The definition...
Virtual care pathways for people living with HIV: A mixed-methods systematic review
BACKGROUND: The COVID-19 pandemic prompted an unprecedented surge in virtual services, necessitating a rapid shift to digital healthcare approaches. This review focuses on evaluating the evidence of virtual care (VC)...
Managing low-level HIV viraemia in antiretroviral therapy: a systematic review and meta-analysis
OBJECTIVE: HIV-1 management has advanced significantly with antiretroviral therapy (ART), yet challenges persist, including low-level HIV-1 viraemia (LLV). LLV presents a complex scenario, with varied definitions in the literature, reflecting...
Management of low-level HIV viremia during antiretroviral therapy: Delphi consensus statement and appraisal of the evidence
Objective While antiretroviral therapy (ART) is highly effective, detection of low levels of HIV-1 RNA in plasma is common in treated individuals. Given the uncertainties on the topic, we convened...
State of HIV costing in Latin America and the Caribbean: A systematic literature review
OBJECTIVES: To summarize available data on unit costs for human immunodeficiency virus (HIV) testing, prevention, and care interventions in Latin America and the Caribbean. METHODS: We conducted a systematic literature...
Innovative pre-exposure prophylaxis interventions among adolescent girls and young women during COVID-19 lockdown period in sub-Saharan Africa: A systematic review
Adolescent girls and young women are key, and priority populations impacted by a higher risk of acquiring human immunodeficiency virus. In 2015, pre-exposure prophylaxis was introduced as a biomedical human...
Efficacy and tollerability of INI-based 2-drug regimen in virosuppressed persons living with HIV: A systematic review and meta-analysis
BACKGROUND: The aim of this meta-analysis was to synthesize the available evidence from the literature on the efficacy and safety of integrase inhibitor-based two drug regimens compared to triple drug...
Treatment failure among Sub-Sahara African children living with HIV: A systematic review and meta-analysis
BACKGROUND: Antiretroviral treatment failure is a global issue, particularly in developing countries such as Sub-Saharan Africa. Prior research findings were highly variable and inconsistent across areas. As a result, the...
