Category Archives: Prevention, Engagement and Care Cascade
HIV infection and antiretroviral therapy impair liver function in people living with HIV: Systematic review and meta-analysis
Background: The use of antiretroviral therapy (ART) has improved the lives of people living with HIV (PLWH). However, its use is associated with secondary complications, notably hepatotoxicity. This systematic review and...
HIV, hepatitis, and syphilis self-testing among adolescents and young adults: A systematic review and meta-analysis
Background: Adolescents and young adults (AYA) make up a significant share of the world’s burden of HIV and other sexually transmitted infections (STI). Self-testing can increase testing coverage and strengthen the...
Meta-analysis of TB & HIV co-infection mortality rate in sub-Saharan African children, youth, and adolescents
Background Despite the effectiveness of antiretroviral treatment (ART) in reducing morbidity and mortality, children and adolescents with co-infections face an elevated risk of death due to their young age and...
Undetectable = Untransmittable: A cross-population systematic review and meta-analysis on awareness and acceptance
The Undetectable = Untransmittable (U=U) message is a cornerstone of HIV-related public health communication, yet global levels of awareness and acceptance remain unclear across key populations. This study aimed to...
Immune responses to vaginal candidiasis in African women: A scoping review of cytokine profiles, T-cell activation, and gene expression
Background Recent immunological studies of vaginal candidiasis in African populations have revealed complex host‒pathogen interactions with implications for therapeutic development and HIV acquisition risk. Objective This scoping review synthesized evidence...
Adolescents’ sexual health during the COVID-19 outbreak: A systematic review
BACKGROUND AND AIMS: The COVID-19 pandemic has greatly disrupted adolescents’ access to sexual health services, resulting in a decline in their overall sexual well-being. This systematic review explored adolescent sexual...
Family influences on antiretroviral therapy adherence in youth with HIV in the United States: A systematic review
HIV poses a significant issue in the United States and understanding how HIV-positive populations adhere to treatments, specifically with antiretroviral therapy (ART), is vital for researchers to find approaches to...
Depression and associated factors among human immunodeficiency virus-positive pregnant women in sub-Saharan Africa: Systematic review and meta-analysis
BACKGROUND: Despite its severe impact on both maternal and fetal health, antenatal depression has not received as much attention in the healthcare community as postnatal depression. Comprehensive evidence is very...
Effectiveness of digital health interventions in promoting the pre-exposure prophylaxis (PrEP) care continuum among men who have sex with men (MSM): A systematic review of randomized controlled trials
PURPOSE OF REVIEW: Digital health interventions have demonstrated great potential to advance HIV prevention and care. However, their effectiveness in improving the pre-exposure prophylaxis (PrEP) care continuum has not yet...
