Category Archives: Prevention, Engagement and Care Cascade
Oral pre-exposure prophylaxis (PrEP) to prevent HIV: A systematic review and meta-analysis of clinical effectiveness, safety, adherence and risk compensation in all populations
OBJECTIVE: To conduct a systematic review and meta-analysis of randomised controlled trials (RCTs) of the effectiveness and safety of oral pre-exposure prophylaxis (PrEP) to prevent HIV. METHODS: Databases (PubMed, Embase...
Interventions addressing the adolescent HIV continuum of care in South Africa: A systematic review and modified Delphi analysis
INTRODUCTION: Compared with adults, adolescents in South Africa have larger gaps at each step of the HIV continuum of care resulting in low levels of viral suppression. METHODS: We conducted...
HIV antiretroviral medication neuropenetrance and neurocognitive outcomes in HIV+ adults: A review of the literature examining the central nervous system penetration effectiveness score
This literature review summarizes the existing research examining the CNS penetration effectiveness (CPE) score and neurocognitive outcomes (i.e., neuropsychological assessment and neurocognitive screening) in HIV+ individuals. Despite the effectiveness of...
Women living with HIV and dual contraceptive use in Ethiopia: Systematic review and meta-analysis
Background Despite different preventive strategies that have been implemented in the country, the prevalence of HIV/AIDS is still significantly increasing in Ethiopia. The concurrence of HIV and unintended pregnancy makes...
Viral load monitoring for people living with HIV in the era of test and treat: progress made and challenges ahead—A systematic review
BACKGROUND: In 2016, we conducted a systematic review to assess the feasibility of treatment monitoring for people living with HIV (PLHIV) receiving antiretroviral therapy (ART) in low and middle-income countries...
The effect of antiretroviral therapy with high central nervous system penetration on HIV-related cognitive impairment: A systematic review and meta-analysis
Chronic complications are a significant concern for people living with HIV/AIDS (PLWHA) infection. HIV-associated neurocognitive disorders (HAND) are prevalent in PLWHA. Yet, the efficacy of medications that penetrate the central...
Cabotegravir: The first long-acting injectable for HIV preexposure prophylaxis
OBJECTIVE: Review the pharmacology, pharmacokinetics, efficacy, safety, and role of long-acting injectable cabotegravir (CAB-LA) in HIV preexposure prophylaxis (PrEP). DATA SOURCES: A literature search was performed using PubMed and Google...
Voluntary counseling and testing, antiretroviral therapy access, and HIV-related stigma: Global progress and challenges
To date, about 37 million people are living with the human immunodeficiency virus (HIV) and an estimated 680,000 people have died from acquired immune deficiency syndrome (AIDS) related illnesses globally....
Strategies to improve HIV care outcomes for people with HIV who are out of care
Objective: The aim of this study was to evaluate the effectiveness of five intervention strategies: patient navigation, appointment help/alerts, psychosocial support, transportation/appointment accompaniment, and data-to-care on HIV care outcomes among persons...
Public availability of HIV-1 drug resistance sequence and treatment data: A systematic review
HIV-1 pol sequences from antiretroviral therapy (ART)-naive and ART-experienced people living with HIV-1 are fundamental to understanding the genetic correlates and epidemiology of HIV-1 drug resistance (HIVDR). To assess the public availability...
The Italian PrEPventHIV challenge: A scoping systematic review on HIV pre-exposure prophylaxis monitoring in Italy
BACKGROUND AND AIM: In Italy, pre-exposure prophylaxis (PrEP) with emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) was authorized for HIV prevention in 2017. This scoping systematic review summarizes current evidence on...
HIV pre-exposure prophylaxis and its impact on the gut microbiome in men having sex with men
HIV/AIDS still imposes a high epidemiological and societal burden. Together with antiretroviral therapy, pre-exposure prophylaxis (PrEP) represents a fundamental tool in the fight against HIV/AIDS. PrEP is considered effective and...
