Category Archives: Prevention, Engagement and Care Cascade
Cost-effectiveness of HIV prevention strategies: A systematic review of economic evaluations
BACKGROUND: HIV/AIDS continues to pose a significant global health challenge, especially in low- and middle-income countries. Economic evaluations are essential to identify cost-effective prevention strategies and allocate limited healthcare resources...
Rapid start with bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) as initial treatment in people with human immunodeficiency virus-1 (HIV-1): A systematic literature review of clinical and patient-reported outcomes
BACKGROUND: Treatment guidelines recommend rapid antiretroviral therapy (ART) initiation among eligible people with HIV to improve treatment outcomes and reduce HIV transmission. Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF), an integrase strand transfer inhibitor-based...
The impact of antiretroviral therapy (ART) on HPV persistence and cervical cancer progression among women with HPV/HIV co-infection: A systematic review
Cervical cancer remains the leading cause of cancer-related morbidity and mortality among women globally, particularly in low- and middle-income countries. Women living with HIV are at risk of persistent high-risk...
HIV infection is associated with accelerated epigenetic ageing: A systematic review
PURPOSE: We conducted a systematic review of studies comparing the intensity of epigenetic ageing in people living with human immunodeficiency virus (HIV) and uninfected individuals. We included studies that quantitatively...
State of HIV research in Venezuela: A systematic review
BACKGROUND: Venezuela’s recent economic and political instability has severely compromised its healthcare infrastructure, impacting the management of infectious diseases, including human immunodeficiency virus (HIV). This disruption hinders progress towards the...
Probability of vertical HIV transmission: A systematic review and meta-regression
Background Eliminating HIV vertical transmission is a global priority and monitored by estimating paediatric HIV infections with the UNAIDS-supported Spectrum AIDS Impact Module (Spectrum-AIM). Recent innovations in antiretroviral therapy (ART)...
Virologic Failure and Emergent Integrase Strand Transfer Inhibitor Drug Resistance With Long-Acting Cabotegravir for HIV Treatment: A Meta-analysis
BACKGROUND: The long-acting injectable regimen of cabotegravir plus rilpivirine (CAB/RPV) emerged as an alternative to oral standard-of-care integrase strand transfer inhibitor (INSTI)-based regimens for individuals with adherence challenges or preference...
HIV-related mortality time trends among children and young adolescents on antiretroviral therapy by age, treatment duration, and region: A systematic review and meta-regression analysis
Background: Past cohort studies have examined mortality among children and young adolescents (aged 0–14 years) who have received antiretroviral therapy (ART), but no systematic reviews have been undertaken to synthesise these...
Cost-effectiveness of HIV prevention interventions in sub-Saharan Africa (2019-2025): A systematic review
INTRODUCTION: This systematic review synthesizes recent evidence on the cost-effectiveness of HIV prevention interventions in sub-Saharan Africa (SSA), where over 70% of the global HIV burden resides. METHODS: Following PRISMA...
Network meta-analytical investigations of the performance of HIV combination prevention strategies for Indigenous populations
BACKGROUND: Indigenous populations worldwide face a disproportionate burden of HIV due to structural inequities, cultural marginalization, and limited access to health services. Despite growing recognition of the need for culturally...
