Category Archives: Prevention, Engagement and Care Cascade
Oral pre-exposure prophylaxis (PrEP) to prevent HIV: A systematic review and meta-analysis of clinical effectiveness, safety, adherence and risk compensation in all populations
OBJECTIVE: To conduct a systematic review and meta-analysis of randomised controlled trials (RCTs) of the effectiveness and safety of oral pre-exposure prophylaxis (PrEP) to prevent HIV. METHODS: Databases (PubMed, Embase...
Interventions addressing the adolescent HIV continuum of care in South Africa: A systematic review and modified Delphi analysis
INTRODUCTION: Compared with adults, adolescents in South Africa have larger gaps at each step of the HIV continuum of care resulting in low levels of viral suppression. METHODS: We conducted...
HIV antiretroviral medication neuropenetrance and neurocognitive outcomes in HIV+ adults: A review of the literature examining the central nervous system penetration effectiveness score
This literature review summarizes the existing research examining the CNS penetration effectiveness (CPE) score and neurocognitive outcomes (i.e., neuropsychological assessment and neurocognitive screening) in HIV+ individuals. Despite the effectiveness of...
Women living with HIV and dual contraceptive use in Ethiopia: Systematic review and meta-analysis
Background Despite different preventive strategies that have been implemented in the country, the prevalence of HIV/AIDS is still significantly increasing in Ethiopia. The concurrence of HIV and unintended pregnancy makes...
Viral load monitoring for people living with HIV in the era of test and treat: progress made and challenges ahead—A systematic review
BACKGROUND: In 2016, we conducted a systematic review to assess the feasibility of treatment monitoring for people living with HIV (PLHIV) receiving antiretroviral therapy (ART) in low and middle-income countries...
The effect of antiretroviral therapy with high central nervous system penetration on HIV-related cognitive impairment: A systematic review and meta-analysis
Chronic complications are a significant concern for people living with HIV/AIDS (PLWHA) infection. HIV-associated neurocognitive disorders (HAND) are prevalent in PLWHA. Yet, the efficacy of medications that penetrate the central...
US Black cisgender women and pre-exposure prophylaxis for human immunodeficiency virus prevention: A scoping review
Background: Black cisgender women in the United States experience a disproportionate burden of human immunodeficiency virus acquisition. Pre-exposure prophylaxis is an effective oral daily medication that reduces the risk of...
Risk of hepatitis C reinfection following successful therapy among people living with HIV: A global systematic review, meta-analysis, and meta-regression
Background: The benefits of direct-acting antivirals towards the elimination of hepatitis C virus (HCV) in people living with HIV are decreased when individuals are reinfected with HCV following treatment. We aimed...
A systematic review of gender-based violence prevention and response interventions for HIV key populations: Female sex workers, men who have sex with men, and people who inject drugs
Gender-based violence (GBV) is that perpetrated based on sex, gender identity, or perceived adherence to socially defined gender norms. This human rights violation is disproportionately experienced by HIV key populations...
Cost-effectiveness of pre-exposure prophylaxis among men who have sex with men in China: A systematic review
OBJECTIVE: Men who have sex with men in China meet the definition of the population at “substantial risk” of contracting human immunodeficiency virus (HIV) according to the World Health Organization;...
The global landscape of the burden of depressive symptoms/major depression in individuals living with HIV/AIDS and its effect on antiretroviral medication adherence: An umbrella review
BACKGROUND: People living with HIV/AIDS have a higher rate of depression/depressive symptoms and this highly affects antiretroviral medication adherence. Therefore, much stronger evidence weighing the burden of depressive symptoms/major depression...
Cabotegravir: The first long-acting injectable for HIV preexposure prophylaxis
OBJECTIVE: Review the pharmacology, pharmacokinetics, efficacy, safety, and role of long-acting injectable cabotegravir (CAB-LA) in HIV preexposure prophylaxis (PrEP). DATA SOURCES: A literature search was performed using PubMed and Google...
