Category Archives: Prevention, Engagement and Care Cascade
Perinatal HIV in Europe: Clinical advances and psychosocial challenges—A scoping review
Despite significant biomedical advances in the prevention of mother-to-child transmission (MTCT) of HIV, residual transmission and suboptimal maternal outcomes persist across Europe. The challenge is no longer primarily virological but...
Efficacy and safety of doravirine/islatravir for HIV-1: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials
Background: The combination of doravirine and islatravir (DOR/ISL) is a novel two-drug regimen for HIV-1. Early development faced challenges due to dose-dependent immunological signals. We aimed to synthesize the evidence on...
Empowering women living with HIV through partner-based interventions: A scoping review
Spouses and partners play a crucial role in the well-being of women living with HIV (WLWH), especially in family-oriented cultures. This scoping review examined partner-inclusive interventions to strengthen support systems...
Culturally competent HIV prevention for African, Caribbean, and Black communities and Indigenous Peoples
Key take-home messages Developing culturally sensitive approaches and materials helps ensure HIV prevention interventions are relevant, acceptable, and responsive to the needs of the intended population groups. Close collaboration with...
Syndemics and clinical impact of HIV and mental health conditions among people living with HIV: A systematic review and meta-analysis
INTRODUCTION: People living with HIV (PLWH) may be exposed to harmful political, social, economic and environmental factors that exacerbate their risk of mental health conditions. Such factors can interact synergistically...
Alcohol use and the care continuum for HIV preexposure prophylaxis: An updated scoping review of research and interventions
Rationale In 2007, WHO issued emergency recommendations on empiric treatment of sputum acid-fast bacillus (AFB) smear-negative patients with possible tuberculosis (TB) in HIV-prevalent areas, and called for operational research to...
Leveraging the barriers and facilitators of pre-exposure prophylaxis (PrEP) care among Latino men who have sex with men in the U.S. to inform intervention: A systematic literature review (2018–2023)
HIV disproportionately affects Latino men who have sex with men (LMSM) in the United States (U.S.). Pre-exposure prophylaxis (PrEP) reduces HIV transmission, but prescription and use rates remain low among...
Experiences and outcomes of peer navigation and support interventions for adolescents on HIV treatment in sub-Saharan Africa: A qualitative evidence synthesis
Adolescents living with HIV (ALHIV) face ongoing challenges with treatment adherence and engagement in care, resulting in lower viral suppression rates compared to adults. Peer navigation has shown promise in...
Effectiveness of pre-exposure prophylaxis (PrEP) in the prevention of human immunodeficiency virus (HIV): A systematic review of randomized controlled trials with narrative synthesis
Human immunodeficiency virus (HIV) prevention has advanced substantially, yet ending new transmissions by 2030 remains uncertain. Pre-exposure prophylaxis (PrEP) has high biological efficacy, but real-world effectiveness varies due to adherence,...
Understanding the implementation of patient navigation for adults living with HIV: A scoping review of components, equity considerations and lessons learned
Background People living with HIV navigate complex medical and social challenges that impact engagement in care, including stigma, poverty and systemic inequities. Patient navigation has emerged as a promising approach...
The global epidemiology of injecting drug use, HIV, viral hepatitis and tuberculosis among people who are incarcerated: A multistage systematic review
Background: This global systematic review assesses the prevalence of injecting drug use (IDU) and key infectious diseases (HIV, hepatitis C virus [HCV], tuberculosis and hepatitis B virus [HBV]) among people...
