Category Archives: Prevention, Engagement and Care Cascade

Best practices of same-day HIV pre-exposure prophylaxis (PrEP) initiation

2021

Several clinics have implemented same-day PrEP programs and have reported that clinics offering this model of care, in general, have positive health outcomes. Studies also report that same-day PrEP is...

The effectiveness of peer-support for people living with HIV: A systematic review and meta-analysis

2021

BACKGROUND: The practice of involving people living with HIV in the development and provision of healthcare has gained increasing traction. Peer-support for people living with HIV is assistance and encouragement...

Clinical outcomes of COVID-19 amongst HIV patients: A systematic literature review

2021

OBJECTIVES: The global pandemic coronavirus disease 2019 (COVID-19) emerged in the city of Wuhan, China around December 2019. Since then, the virus has caused severe morbidity and mortality worldwide and...

Is polygyny a risk factor in the transmission of HIV in sub-Saharan Africa? A systematic review

2021

Using a systematic literature review approach, this paper focused on the role of polygyny in the spread of HIV/AIDS in sub-Saharan Africa (SSA) countries. The widespread practice of polygyny is...

Reviewing PrEP’s effect on STI incidence among men who have sex with men —Balancing increased STI screening and potential behavioral sexual risk compensation

2021

Though pre-exposure prophylaxis (PrEP) can prevent HIV acquisition, it provides no protection against bacterial sexually transmitted infections (STIs). PrEP use may increase STI acquisition due to sexual risk compensation, but...

Association between medical male circumcision and HIV risk compensation among heterosexual men: A systematic review and meta-analysis

2021

BACKGROUND: Medical male circumcision (MMC) reduces HIV infection among heterosexual men. There are concerns MMC might prompt higher-risk sexual behaviours because of lower self-perceived risk of HIV infection. We reviewed...

Immunological treatment failure among adult patients receiving highly active antiretroviral therapy in East Africa: A systematic review and meta-analysis

2021

BACKGROUND: Minimizing antiretroviral treatment failure is crucial for improving patient health and for maintaining long-term access to care in low-income settings such as eastern Africa. To develop interventions to support...

Safety and pharmacokinetic profiles of long-acting injectable antiretroviral drugs for HIV-1 pre-exposure prophylaxis: A systematic review and meta-analysis of randomized trials

2021

Objectives: To investigate the safety and pharmacokinetic profiles of long-acting injectable pre-exposure prophylaxis (LAI PrEP), notably cabotegravir (CAB-LA) and rilpivirine (RPV-LA), for the prevention of human immunodeficiency virus-1 (HIV-1) infection....

Effectiveness of mobile phone text message reminder interventions to improve adherence to antiretroviral therapy among adolescents living with HIV: A systematic review and meta-analysis

2021

BACKGROUND: Poor adherence to antiretroviral therapy in adolescents living with HIV is a global challenge. One of the key strategies to improve adherence is believed to be the use of...

Association of CD4 T cell count and optimal timing of antiretroviral therapy initiation with immune reconstitution inflammatory syndrome and all-cause mortality for HIV-infected adults with newly diagnosed pulmonary tuberculosis: A systematic review and meta-analysis

2021

Aims: CD4 T cell count and optimal timing of antiretroviral therapy (ART) during tuberculosis (TB) treatment are challenging. We conducted a meta-analysis to assess the association of CD4 T cell...

Role of brain arterial remodeling in HIV-associated cerebrovascular outcomes

2021

As the life expectancy of people living with HIV (PLWH) on combination antiretroviral therapy (cART) increases, so does morbidity from cerebrovascular disease and neurocognitive disorders. Brain arterial remodeling stands out...

Breastfeeding inequities in South Africa: Can enforcement of the WHO Code help address them? — A systematic scoping review

2021

INTRODUCTION: Suboptimal breastfeeding rates in South Africa have been attributed to the relatively easy access that women and families have had to infant formula, in part as a result of...

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