Category Archives: Prevention, Engagement and Care Cascade
Same-day antiretroviral therapy initiation for people living with HIV who have tuberculosis symptoms: A systematic review
Objectives Tuberculosis symptoms are very common among people living with HIV (PLHIV) initiating antiretroviral therapy (ART), are not specific for tuberculosis disease and may result in delayed ART start. The...
Association between adherence to antiretroviral therapy and place of residence among adult HIV infected patients in Ethiopia: A systematic review and meta-analysis
BACKGROUND: According to the World Health Organization, optimal adherence to Antiretroviral Therapy (ART) improves quality of life. Patients who use ART have varying characteristics in terms of where they live....
HIV-sensitive social protection for vulnerable young women in East and Southern Africa: A systematic review
Introduction: Social protection programmes are considered HIV-sensitive when addressing risk, vulnerability or impact of HIV infection. Socio-economic interventions, like livelihood and employability programmes, address HIV vulnerabilities like poverty and gender inequality....
Assessing HIV and overdose risks for people who use drugs exposed to compulsory drug abstinence programs (CDAP): A systematic review and meta-analysis
Background: Evidence supports integrating drug use treatment, harm reduction, and HIV prevention services to address dual epidemics of drug use disorders and HIV. These dual epidemics have spurred a rise in...
Strategies for the diagnosis and management of meningitis in HIV-infected adults in resource limited settings
INTRODUCTION: The incidence of human immunodeficiency virus-1 (HIV-1) associated meningitis has been declining in the post-combination antiretroviral treatment (ART) era, although survival rates remain low for the common causes like...
Effectiveness of ezetimibe in human immunodeficiency virus patients treated for hyperlipidaemia: A systematic review and meta-analysis
Objective: Systematic review and meta-analysis of lipid outcomes for human immunodeficiency virus (HIV)-positive or HIV-infected patients treated with ezetimibe. Methods: We conducted a literature search from 1946 to 2021 for trials studying...
Drug resistance mutations in HIV: New bioinformatics approaches and challenges
Drug resistance mutations appear in HIV under treatment pressure. Resistant variants can be transmitted to treatment-naive individuals, which can lead to rapid virological failure and can limit treatment options. Consequently,...
HIV-proteins-associated CNS neurotoxicity, their mediators, and alternative treatments
Human immunodeficiency virus (HIV)-infected people’s livelihoods are gradually being prolonged with the use of combined antiretroviral therapy (ART). Conversely, despite viral suppression by ART, the symptoms of HIV-associated neurocognitive disorder...
TLR-agonist mediated enhancement of antibody-dependent effector functions as strategy for an HIV-1 cure
BACKGROUND: The current treatment for HIV-1 is based on blocking various stages in the viral replication cycle using combination antiretroviral therapy (ART). Even though ART effectively controls the infection, it...
