Category Archives: Prevention, Engagement and Care Cascade
Transmitted drug resistance in antiretroviral therapy-naive persons with acute/early/primary HIV infection: A systematic review and meta-analysis
Background: The widespread use of antiretroviral therapy (ART) has raised concerns about the emergence of HIV transmitted drug resistance (TDR). Acute HIV infection (AHI) was the most appropriate time to detect...
Psychotherapy for comorbid depression and somatic disorders: A systematic review and meta-analysis
BACKGROUND: The treatment of depression in patients with somatic disorders is crucial, given its negative impact on quality of life (QoL), functioning, and even on the somatic disease prognosis. We...
Tuberculosis screening among ambulatory people living with HIV: A systematic review and individual participant data meta-analysis
Background The WHO-recommended tuberculosis screening and diagnostic algorithm in ambulatory people living with HIV is a four-symptom screen (known as the WHO-recommended four symptom screen [W4SS]) followed by a WHO-recommended...
Mother-to-child HIV-2 transmission: Comparison with HIV-1 and evaluation of factors influencing the rate of transmission. A systematic review
A review and collection of data on HIV-2 mother-to-child transmission (MTCT) is absent in the literature. This systematic review and meta-analysis aims to provide a pooled estimate of the rate...
Patient perspectives on integrated healthcare for HIV, hypertension and type 2 diabetes: A scoping review
INTRODUCTION: Antiretroviral therapy has reduced mortality and led to longer life expectancy in people living with HIV. These patients are now at an increased risk of non-communicable diseases (NCDs). Integration...
Barriers to and enablers of uptake of antiretroviral therapy in integrated HIV and tuberculosis treatment programmes in sub-Saharan Africa: A systematic review and meta-analysis
Introduction Programmes that merge management of Human Immunodeficiency Virus (HIV) and tuberculosis (TB) aim to improve HIV/TB co-infected patients’ access to comprehensive treatment. However, several reports from sub-Saharan Africa (SSA)...
Psychosocial interventions to promote undetectable HIV viral loads: A systematic review of randomized clinical trials
Suppressing HIV viral loads to undetectable levels is essential for ending the HIV/AIDS epidemic. We evaluated randomized controlled trials aimed to increase antiretroviral medication adherence and promote undetectable viral loads...
Diabetes mellitus among adults on highly active anti-retroviral therapy and its associated factors in Ethiopia: Systematic review and meta-analysis
Background Diabetes mellitus occurs as a comorbid illness among people living with HIV and, in particular those on Highly Active Anti-retroviral therapies (HAART). Previous studies have documented the prevalence of...
Is tenofovir disoproxil fumarate associated with weight loss?
Background: Recent clinical trials have shown weight gain associated with newer antiretrovirals. It is unclear how the nucleoside reverse transcriptase inhibitor backbone affects weight. Recent evidence suggests greater weight gain with...
Global burden and changing trend of hepatitis C virus infection in HIV-positive and HIV-negative MSM: A systematic review and meta-analysis
Background: The disease burden of hepatitis C virus (HCV) infection in HIV-positive and HIV-negative men who have sex with men (MSM) is changing. We aim to provide an updated comprehensive...
