Category Archives: Prevention, Engagement and Care Cascade

Mechanisms and primary prevention of atherosclerotic cardiovascular disease among people living with HIV

2021

PURPOSE OF REVIEW: To highlight mechanisms of elevated risk of atherosclerotic cardiovascular disease (ASCVD) among people living with HIV (PLWH), discuss therapeutic strategies, and opportunities for primary prevention. RECENT FINDINGS:...

Clinical consequences of asymptomatic cytomegalovirus in treated human immunodeficency virus infection

2021

PURPOSE OF REVIEW: Despite antiretroviral therapy (ART)-mediated viral suppression, people with human immunodeficiency virus (HIV) (PWH) have increased morbidity and mortality. Immune activation and inflammation persist on ART and predict...

Current co-morbidities burden in patients living with HIV in low- and middle-income countries

2021

PURPOSE OF REVIEW: The present review aims to decipher common co-morbidities faced by people living with HIV in low- to middle-income countries, and in particular the sub-Saharan region, which hosts...

Impact of Integrase inhibitors and tenofovir alafenamide on weight gain in people with HIV

2021

PURPOSE OF REVIEW: Obesity is increasing in people with HIV (PWH). This review aims to summarise the recent evidence investigating the associations between the use of integrase inhibitors and tenofovir...

Recent data on adipose tissue, insulin resistance, diabetes and dyslipidaemia in antiretroviral therapy controlled HIV-infected persons

2021

PURPOSE OF REVIEW: Increased total body fat with truncal redistribution is common in antiretroviral therapy (ART)-controlled persons living with HIV(PLWH), leading to insulin resistance, prediabetes/diabetes and dyslipidaemia. We address these...

A review of chronic comorbidities in adults living with HIV: State of the science

2021

People living with HIV are living longer, high-quality lives; however, as they age, this population is at increased risk for developing chronic comorbidities, including cardiovascular disease, certain types of cancer...

The intersection of cognitive ability and HIV: A review of the state of the nursing science

2021

Neurocognitive problems have been endemic to the HIV epidemic since its beginning. Four decades later, these problems persist, but currently, they are attributed to HIV-induced inflammation, the long-term effects of...

Effects of probiotics on diarrhea and CD4 cell count in people living with HIV: A systematic review and meta-analysis

2021

Gastrointestinal probiotics play an important role in maintaining intestinal bacteria homeostasis. They might benefit people with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), which remains a global health challenge. However, there...

Eliminating HIV reservoirs for a cure: The issue is in the tissue

2021

PURPOSE OF REVIEW: Advances in antiretroviral therapy have saved numerous lives, converting a diagnosis with human immunodeficiency virus 1 (HIV-1) from a death sentence into the possibility for a (nearly)...

Assessing proviral competence: Current approaches to evaluate HIV-1 persistence

2021

PURPOSE OF REVIEW: Despite decades of suppressive antiretroviral therapy (ART), HIV-1 reservoirs persist and fuel viral rebound if therapy is interrupted. The persistence of viral reservoirs in infected individuals is...

Increased risk of vitamin D deficiency among HIV-infected individuals: A systematic review and meta-analysis

2021

Background: Human immunodeficiency virus (HIV) infection is a heavy burden worldwide. Observational studies have reported a high prevalence of vitamin D deficiency (VDD) among people living with HIV (PLWH). However,...

Dual contraceptive use and factor associated with people living with HIV/AIDS: A systematic review and meta-analysis

2021

INTRODUCTION: A dual contraceptive method is the usage of any modern contraceptive method with male or female condoms which could lower sexually transmitted diseases and unwanted pregnancy. Ethiopian standard utilization...

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