Category Archives: Prevention, Engagement and Care Cascade
Determinants of HIV related mortality in African children on antiretroviral therapy: Clinical and immunological insights from a systematic review and meta-analysis
BACKGROUND: The HIV epidemic in Africa is still a serious public health concern, particularly for children who are more vulnerable to its negative consequences. Various studies carried out in different...
Motivations, facilitators, and barriers of donation-based interventions in HIV and sexually transmitted infection research: A systematic review
IMPORTANCE: Donation-based prosocial interventions involve someone receiving a free health service and then distributing or donating to support health services for others; examples within the HIV and sexually transmitted infection...
Hepatitis C increases acute myocardial infarction risk in people living with HIV: A systematic review and meta-analysis
BackgroundHepatitis C virus (HCV) coinfection is common among people living with HIV (PLWH) and is associated with adverse outcomes. However, the specific association between HCV coinfection and the risk of...
Performance of adherence measures for oral, tenofovir-based HIV pre-exposure prophylaxis: A systematic review
Accurate adherence measures to HIV pre-exposure prophylaxis (PrEP) are essential for identifying individuals with low adherence and providing tailored support. This systematic review summarizes evidence on the performance of PrEP...
Intermittent preventive treatment regimens for malaria in HIV-positive pregnant women: Systematic review and meta-analysis of clinical trials
Background: The WHO recommended the use of intermittent preventive treatment (IPT) regimens for malaria in HIV-positive pregnant women living in endemic areas to prevent malaria-related perinatal complications. However, the high drug...
Prevalence and factors associated with HIV viral rebound in individuals on ART: A systematic review study
BACKGROUND: Viral rebound (VR), the resurgence of detectable human immunodeficiency virus (HIV) viral loads (> 50 copies/mL) after suppression, remains a challenge for individuals on antiretroviral therapy (ART) in South...
Advanced stage disease progression and mortality rate before and after the implementation of the Universal Test and Treat strategy (UTT) for HIV patients in Ethiopia: A systematic review and meta-analysis
BACKGROUND: The universal test and treat (UTT) program, is a strategy for eliminating HIV and, it involves screening all populations at risk for HIV infection, initiating early treatment for those...
Seroprevalence of transfusion-transmitted infections among blood donors in India: A systematic review and meta-analysis
BACKGROUND AND OBJECTIVES: Blood transfusion is essential in healthcare but carries inherent risks of human immunodeficiency virusAÿ(HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis and malaria transmission. National...
Breastfeeding knowledge, attitudes and practices of HIV-positive women in Africa: A systematic review
BACKGROUND: Breastfeeding is essential for ensuring the health and survival of children, particularly in regions where diarrhoea, pneumonia and malnutrition are common causes of child mortality. In sub-Saharan Africa, over...
The outcomes of cryptococcal disease in HIV-positive individuals following COVID-19 infection: A systematic review and meta-analysis
Background: Cryptococcal disease is considered a major cause of morbidity in individuals with HIV in resource-limited settings. The long-term effects of COVID-19 and cryptococcal coinfection among people living with HIV (PLWHIV)...
Immunogenicity and safety of the booster COVID-19 vaccine among people with HIV: A systematic review and meta-analysis
Background Human immunodeficiency virus (HIV) and COVID-19 continue to pose significant global public health challenges. Although vaccination is essential for preventing COVID-19 in people with HIV (PWH), evidence on the...
