Category Archives: Prevention
Interventions to reduce sexual risk for human immunodeficiency virus in adolescents: A meta-analysis of trials, 1985-2008
OBJECTIVE: To provide an updated review of the efficacy of behavioral interventions to reduce sexual risk of human immunodeficiency virus (HIV) among adolescents. DESIGN: We searched electronic databases, leading public...
Behavioral interventions to reduce HIV-related sexual risk behavior: review and synthesis of meta-analytic evidence
Over the past 25 years, scores of behavioral interventions to reduce HIV-related sexual risk behavior have been developed and evaluated. The purpose of the current study was to synthesize what...
School-based programs to reduce sexual risk behaviors: A review of effectiveness
This review was undertaken in recognition of the mounting public health and social problems associated with adolescent sexual behavior and the importance of basing school-affiliated programs designed to reduce sexual...
Screening for HIV: Systematic review to update the 2005 U.S. Preventive Services Task Force recommendation
BACKGROUND: A 2005 U.S. Preventive Services Task Force (USPSTF) review found good evidence that HIV screening is accurate and that antiretroviral therapy (ART) for immunologically advanced disease is associated with...
Systematic review of abstinence-plus HIV prevention programs in high-income countries
BACKGROUND: Abstinence-plus (comprehensive) interventions promote sexual abstinence as the best means of preventing HIV, but also encourage condom use and other safer-sex practices. Some critics of abstinence-plus programs have suggested...
Utilizing buprenorphine-naloxone to treat illicit and prescription-opioid dependence
OBJECTIVES: To review current evidence on buprenorphine-naloxone (bup/nx) for the treatment of opioid-use disorders, with a focus on strategies for clinical management and office-based patient care. QUALITY OF EVIDENCE: Medline...
HIV and HCV prevalence among entrants to methadone maintenance treatment clinics in China: A systematic review and meta-analysis
Background: Methadone maintenance treatment (MMT) was implemented in China since 2004. It was initiated in 8 pilot clinics and subsequently expanded to 738 clinics by the end of 2011. Numerous...
Cost-effectiveness of antenatal HIV-testing: Reviewing its pharmaceutical and methodological aspects
This paper reviews the pharmacoeconomic aspects of antenatal testing for HIV. HIV is a retrovirus which is transmitted among humans through sexual contact, infected blood or blood products (needle sharing...
Effect of CCR5-delta32 heterozygosity on the risk of perinatal HIV-1 infection: A meta-analysis
Several studies have investigated whether heterozygosity for a 32-basepair deletion in the CC chemokine receptor 5 gene (CCR5-Delta32 ) affects susceptibility to perinatal HIV-1 infection, but results have been inconclusive....
Analytic review of modeling studies of ARV Based PrEP interventions reveals strong influence of drug-resistance assumptions on the population-level effectiveness
BACKGROUND: Four clinical trials have shown that oral and topical pre-exposure prophylaxis (PrEP) based on tenofovir may be effective in preventing HIV transmission. The expected reduction in HIV transmission and...
